Faergemann J
Department of Dermatology, University of Gothenburg, Sahlgren's Hospital, Gothenburg, Sweden.
Ann N Y Acad Sci. 1988;544:348-53. doi: 10.1111/j.1749-6632.1988.tb40419.x.
The in vitro antimycotic activity and the in vivo antimycotic activity (in a rabbit model) of itraconazole against P. orbiculare were compared to the corresponding activities of ketoconazole. Fluconazole's in vitro antimycotic activity and in vivo antimycotic activity against P. orbiculare were tested in the same models. The MIC values of itraconazole against P. orbiculare were 0.1-0.2 micrograms/ml compared to 0.02-0.05 micrograms/ml for ketoconazole. For fluconazole, the MIC values were 12.5-50.0 micrograms/ml against P. orbiculare. In a rabbit model, orally administered itraconazole (5 mg/kg) afforded protection against experimental pityriasis (tinea) versicolor in four out of five rabbits. Ketoconazole (1 mg/kg) was effective in all four animals. The in vivo results with fluconazole were in contrast to its low in vitro activity. Fluconazole (5 mg/kg) afforded protection against experimental pityriasis (tinea) versicolor in five out of six animals.
将伊曲康唑针对圆形糠秕孢子菌的体外抗真菌活性和体内抗真菌活性（在兔模型中）与酮康唑的相应活性进行了比较。在相同模型中测试了氟康唑针对圆形糠秕孢子菌的体外抗真菌活性和体内抗真菌活性。伊曲康唑针对圆形糠秕孢子菌的MIC值为0.1 - 0.2微克/毫升，而酮康唑为0.02 - 0.05微克/毫升。对于氟康唑，针对圆形糠秕孢子菌的MIC值为12.5 - 50.0微克/毫升。在兔模型中，口服伊曲康唑（5毫克/千克）使五只兔子中的四只免受实验性花斑癣（癣）的侵害。酮康唑（1毫克/千克）对所有四只动物均有效。氟康唑的体内结果与其低体外活性形成对比。氟康唑（5毫克/千克）使六只动物中的五只免受实验性花斑癣（癣）的侵害。
