Todd Neil P M, Govender Sendhil, Colebatch James G
Department of Psychology, University of Exeter , United Kingdom.
Prince of Wales Clinical School, University of New South Wales , Sydney, New South Wales , Australia.
J Neurophysiol. 2018 Dec 1;120(6):3099-3109. doi: 10.1152/jn.00502.2018. Epub 2018 Oct 17.
We recorded evoked potentials (EPs) from over the posterior fossa and in parallel ocular vestibular evoked myogenic potentials (OVEMPs) during visuo-vestibular stimulation in a sample of 7 male and 11 female human subjects. In 9 of the 18 subjects we were able to record EPs reliably in the form of an early biphasic positive-negative wave with latencies ~12 and 17 ms ipsilateral to head acceleration direction (P12-N17) and a slightly later, contralateral, biphasic positive-negative wave with latencies ~19 and 23 ms (P19-N23). The amplitudes of the responses varied widely between subjects. Both P12 and N23 EPs were modulated by the mode of visual stimulation, larger for vection (sense of movement) compared with optokinetic nystagmus and for congruent movement. We suggest that the EPs measured over the posterior fossa are a manifestation of climbing fiber responses of cerebellar cortical Purkinje cells, i.e., a form of vestibular cerebellar EP (VsCEP). The two subject groups with and without VsCEPs were distinguished by the magnitude of their OVEMPs and their subjective experience of vection. The modulation of VsCEPs by visual context may be a manifestation of cerebellar control of linear vestibular ocular reflex gain. NEW & NOTEWORTHY We report likely vestibular cerebellar evoked potentials (VsCEPs) produced by lateral head impulses recorded in intact humans over the posterior fossa. VsCEPs occurred as short-latency P12-N17 waves ipsilateral to the direction of head motion and as P19-N23 contralaterally and were present in half our subjects. Their properties suggest that the VsCEPs may be of a climbing-fiber origin. VsCEPs are related to the perception of motion and, possibly, control of linear vestibular ocular reflex gain.
我们在7名男性和11名女性人类受试者样本中，于视觉 - 前庭刺激期间记录了后颅窝上方的诱发电位（EP），并同时记录了眼前庭诱发肌源性电位（OVEMP）。在18名受试者中的9名中，我们能够可靠地记录到EP，其表现为早期双相正负波，在头部加速度方向同侧的潜伏期约为12和17毫秒（P12 - N17），以及稍晚出现的对侧双相正负波，潜伏期约为19和23毫秒（P19 - N23）。不同受试者之间反应的幅度差异很大。P12和N23 EP均受视觉刺激模式的调制，相对于视动性眼震和一致运动，在运动错觉（运动感）时更大。我们认为，在后颅窝上方测量到的EP是小脑皮质浦肯野细胞攀缘纤维反应的一种表现，即一种前庭小脑EP（VsCEP）形式。有和没有VsCEP的两组受试者通过其OVEMP的大小和他们的运动错觉主观体验来区分。视觉环境对VsCEP的调制可能是小脑对线性前庭眼反射增益控制的一种表现。新发现与值得注意的我们报告了在完整人类后颅窝记录到的由侧向头部冲动产生的可能的前庭小脑诱发电位（VsCEP）。VsCEP表现为与头部运动方向同侧的短潜伏期P12 - N17波和对侧的P19 - N23波，在我们一半的受试者中出现。它们的特性表明VsCEP可能起源于攀缘纤维。VsCEP与运动感知有关，并且可能与线性前庭眼反射增益的控制有关。
