Laboratory of Renal Lithiasis Research, University Institute of Health Sciences Research (IUNICS-IdISBa), University of Balearic Islands, Ctra. Valldemossa km 7.5, 07122 Palma de Mallorca, Spain.
Nutrients. 2018 Oct 16;10(10):1516. doi: 10.3390/nu10101516.
The purpose of this study was to determine the effects of consumption of different cocoa-derived products on uric acid crystallization in urine of 20 healthy volunteers. Participants were requested to select the specific diet that they wished to follow during the 12 h prior to collection of urine. The only restriction was that the diet could not include any product with cocoa, coffee, or caffeine. On the first day, each volunteer followed their selected diet, and an overnight 12 h urine sample was collected as the baseline urine. After seven days on an unrestricted diet, each volunteer repeated the same diet with 20 g of milk chocolate, chocolate powder, or dark chocolate during breakfast and another 20 g during dinner. Overnight 12 h urine samples were then collected. Urine volume, pH, oxalate, creatinine, uric acid, theobromine, and a uric acid crystallization test were determined for each sample. The results for all 20 patients show that uric acid crystallization was significantly lower following the consumption of chocolate powder or dark chocolate relative to baseline or following the consumption of milk chocolate. The results indicated that increased concentrations of urinary theobromine reduced the risk of uric acid crystallization.
本研究旨在确定摄入不同可可制品对 20 名健康志愿者尿液中尿酸结晶的影响。参与者被要求选择在收集尿液前 12 小时内希望遵循的特定饮食。唯一的限制是饮食不能包括任何含有可可、咖啡或咖啡因的产品。第一天，每个志愿者都遵循他们选择的饮食，收集 12 小时的过夜尿液作为基线尿液。在无限制饮食七天后，每个志愿者在早餐和晚餐时分别再吃 20 克牛奶巧克力、巧克力粉或黑巧克力，然后再次收集 12 小时的过夜尿液样本。对每个样本的尿量、pH 值、草酸盐、肌酐、尿酸、可可碱和尿酸结晶试验进行了测定。所有 20 名患者的结果均表明，与基线相比，或与摄入牛奶巧克力相比，摄入巧克力粉或黑巧克力后，尿酸结晶明显降低。结果表明，尿可可碱浓度的增加降低了尿酸结晶的风险。
