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姑息性放疗后经全身化疗成功治疗的纵隔大细胞神经内分泌癌

Large Cell Neuroendocrine Carcinoma of the Mediastinum Successfully Treated with Systemic Chemotherapy after Palliative Radiotherapy.

作者信息

Hidaka Takeaki, Okuzumi Saki, Matsuhashi Ako, Takahashi Hidenori, Hata Kazunori, Shimizu Seiichiro, Iwasaki Yoshinobu

机构信息

Department of Respiratory Medicine, Showa General Hospital, Japan.

Department of General Thoracic Surgery, Showa General Hospital, Japan.

出版信息

Intern Med. 2019 Feb 15;58(4):563-568. doi: 10.2169/internalmedicine.0437-17. Epub 2018 Oct 17.

DOI:10.2169/internalmedicine.0437-17
PMID:30333385
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6421155/
Abstract

Large cell neuroendocrine carcinoma (LCNEC) is a highly malignant cancer originally found in lung in 1991. In extremely rare occasions, primary LCNEC is found in the mediastinum; approximately 40 of such cases have been reported. Due to the limited number of reported cases, a standardized treatment protocol has yet to be established. We report a case of a 66-year-old woman with primary mediastinal LCNEC who presented with superior vena cava syndrome. Emergent radiotherapy was performed, followed by systemic chemotherapy with cisplatin and etoposide, which resulted in a dramatic tumor reduction. This is the first report describing the achievement of a complete response after systemic chemotherapy in a patient with primary LCNEC.

摘要

大细胞神经内分泌癌（LCNEC）是一种高度恶性的癌症，于1991年首次在肺部被发现。在极其罕见的情况下，原发性LCNEC可发生于纵隔；此类病例约报告了40例。由于报告的病例数量有限，尚未建立标准化的治疗方案。我们报告一例66岁患有原发性纵隔LCNEC并出现上腔静脉综合征的女性患者。先行紧急放疗，随后采用顺铂和依托泊苷进行全身化疗，肿瘤显著缩小。这是首例描述原发性LCNEC患者经全身化疗后达到完全缓解的报告。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c806/6421155/e46a47d9d0c0/1349-7235-58-0563-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c806/6421155/dbeb7b7a4911/1349-7235-58-0563-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c806/6421155/e7888261fed2/1349-7235-58-0563-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c806/6421155/95494c31fe48/1349-7235-58-0563-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c806/6421155/e46a47d9d0c0/1349-7235-58-0563-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c806/6421155/dbeb7b7a4911/1349-7235-58-0563-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c806/6421155/e7888261fed2/1349-7235-58-0563-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c806/6421155/95494c31fe48/1349-7235-58-0563-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c806/6421155/e46a47d9d0c0/1349-7235-58-0563-g004.jpg

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