类风湿关节炎合并抗黑色素瘤分化相关基因5抗体阳性间质性肺炎
Rheumatoid Arthritis Complicated with Anti-melanoma Differentiation-associated Gene 5 Antibody-positive Interstitial Pneumonia.
作者信息
Matsumoto Haruki, Sato Shuzo, Fujita Yuya, Yashiro-Furuya Makiko, Matsuoka Naoki, Asano Tomoyuki, Kobayashi Hiroko, Watanabe Hiroshi, Migita Kiyoshi
机构信息
Department of Rheumatology, Fukushima Medical University School of Medicine, Japan.
出版信息
Intern Med. 2019 Mar 1;58(5):737-742. doi: 10.2169/internalmedicine.1613-18. Epub 2018 Oct 17.
Abstract
Anti-melanoma differentiation-associated gene 5 (MDA5) antibodies are frequently detected in amyopathic dermatomyositis with rapidly progressive interstitial lung disease (RP-ILD). However, the presence of anti-MDA5 antibodies in other connective tissue diseases is not well known. We herein report a case of rheumatoid arthritis complicated with refractory anti-MDA5 antibody-positive ILD. A 75-year-old Japanese woman was referred to our hospital for refractory ILD. Serological testing was positive for anti-MDA5 antibody without any muscle or skin lesions. Immunosuppressive therapy (prednisolone and tacrolimus) ameliorated her symptoms as well as ILD. Anti-MDA5 antibody-positive ILD, as well as dermatomyositis with RP-ILD, can occur in patients with rheumatoid arthritis.
摘要
抗黑色素瘤分化相关基因5（MDA5）抗体在伴有快速进展性间质性肺病（RP-ILD）的无肌病性皮肌炎中经常被检测到。然而，抗MDA5抗体在其他结缔组织疾病中的存在情况尚不清楚。我们在此报告一例类风湿关节炎合并难治性抗MDA5抗体阳性ILD的病例。一名75岁的日本女性因难治性ILD转诊至我院。血清学检测显示抗MDA5抗体呈阳性，且无任何肌肉或皮肤病变。免疫抑制治疗（泼尼松龙和他克莫司）改善了她的症状以及ILD。抗MDA5抗体阳性ILD以及伴有RP-ILD的皮肌炎可发生于类风湿关节炎患者中。
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