碳酸钠促进α-卤代羟肟酸酯和异氰酸酯的[3+2]环加成反应。
Sodium carbonate promoted [3 + 2] annulation of α-halohydroxamates and isocyanates.
机构信息
Non-power Nuclear Technology Collaborative Innovation Center, School of Nuclear Technology and Chemistry & Biology, Hubei University of Science and Technology, Xianning, 437100, China.
出版信息
Org Biomol Chem. 2018 Nov 7;16(43):8011-8014. doi: 10.1039/c8ob02321b.
PMID:30334046
Abstract
A new [3 + 2] annulation of readily available α-halohydroxamates and isocyanates has been developed. This protocol allows a rapid assembly of various hydantoins in good to high yields as well as a broad substrate scope and good functional group tolerance.
摘要
一种新的[3+2]环化反应已经被开发出来，用于易得的α-卤代羟胺和异氰酸酯。该方法可以快速构建各种海因类化合物，产率高，底物适用范围广，官能团容忍性好。
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