无过渡金属的碘化钾催化 4-苯胺基香豆素的 Bunte 盐区域选择性硫代反应。
Transition-metal-free KI-catalyzed regioselective sulfenylation of 4-anilinocoumarins using Bunte salts.
机构信息
School of Chemistry and Chemical Engineering, Qufu Normal University, Qufu 273165, Shandong, P. R. China.
出版信息
Org Biomol Chem. 2018 Nov 7;16(43):8015-8019. doi: 10.1039/c8ob02268b.
PMID:30334050
Abstract
An efficient and eco-friendly protocol for the KI-catalyzed regioselective sulfenylation of 4-anilinocoumarins with Bunte salts was established. The reaction worked smoothly under metal-free conditions and afforded a wide range of sulfenylated 4-anilinocoumarins with potential bioactivity in moderate to excellent yields. This method would expand the still limited scope of synthesis methods for C-S bond formation using Bunte salts.
摘要
建立了一种高效、环保的 KI 催化 4-苯胺基香豆素与 Bunte 盐的区域选择性亚磺化反应协议。该反应在无金属条件下顺利进行，提供了广泛的具有潜在生物活性的亚磺化 4-苯胺基香豆素，产率中等至优秀。该方法将扩展使用 Bunte 盐形成 C-S 键的合成方法的有限范围。
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