Değirmenci Mehmet Fatih Kağan, Demirel Sibel, Batıoğlu Figen, Özmert Emin
Department of Ophthalmology, Faculty of Medicine, Vehbi Koç Eye Hospital, Ankara University, Mamak Street, Dikimevi, Ankara, Turkey.
Doc Ophthalmol. 2018 Dec;137(3):131-141. doi: 10.1007/s10633-018-9656-8. Epub 2018 Oct 17.
To determine if the RETeval system can be used for the screening of diabetic retinopathy (DR) to provide early diagnosis.
The subjects were 42 diabetic patients selectively recruited by examination of their medical records to have varying severities of DR. The severity of DR was classified into four groups according to the International Clinical Diabetic Retinopathy Disease Severity Scale. Full-field electroretinograms (ERG) without mydriasis were obtained by the DR assessment protocol of the RETeval system. Macular retinal nerve fiber layer (RNFL) thickness was measured by optical coherence tomography. We compared the DR assessment protocol results and the macular RNFL thickness among four groups. Moreover, an analysis was conducted on whether there was any correlation among the DR assessment protocol results, duration of diabetes mellitus, and RNFL thickness individually for each group of patients.
The mean ages and mean duration of diabetes mellitus of the four groups were similar. The DR assessment protocol results in the moderate-severe nonproliferative DR, and proliferative DR groups were significantly higher than those in the other groups (p < 0.001). The mean macular RNFL thickness was similar in all groups. No significant correlation was found between the DR assessment protocol results and duration of DM and the RNFL thickness.
Our results suggest that the RETeval full-field ERG system can be used as an adjunctive tool for the mass screening of DR, while macular RNFL thickness would not be useful.
确定RETeval系统是否可用于糖尿病视网膜病变（DR）的筛查以实现早期诊断。
通过检查病历选择性招募了42例患有不同严重程度DR的糖尿病患者。根据国际临床糖尿病视网膜病变疾病严重程度量表，将DR的严重程度分为四组。采用RETeval系统的DR评估方案在未散瞳的情况下获取全视野视网膜电图（ERG）。通过光学相干断层扫描测量黄斑视网膜神经纤维层（RNFL）厚度。我们比较了四组之间的DR评估方案结果和黄斑RNFL厚度。此外，针对每组患者，分别分析了DR评估方案结果、糖尿病病程和RNFL厚度之间是否存在相关性。
四组患者的平均年龄和糖尿病平均病程相似。中度至重度非增殖性DR组和增殖性DR组的DR评估方案结果显著高于其他组（p < 0.001）。所有组的黄斑RNFL平均厚度相似。未发现DR评估方案结果与糖尿病病程及RNFL厚度之间存在显著相关性。
我们的结果表明，RETeval全视野ERG系统可作为DR大规模筛查的辅助工具，而黄斑RNFL厚度并无用处。
