Rehfeld J F, Lindholm J, Andersen B N, Bardram L, Cantor P, Fenger M, Lüdecke D K
N Engl J Med. 1987 May 14;316(20):1244-7. doi: 10.1056/NEJM198705143162004.
We found small amounts of cholecystokinin in the normal human adenohypophysis and therefore examined pituitary tumors from 87 patients with acromegaly, Cushing's disease, Nelson's syndrome, prolactinoma, or inactive pituitary adenomas. Five adenomas associated with Nelson's syndrome contained increased amounts of cholecystokinin, the concentrations being extremely high in two: 8281 and 13,453 pmol per gram as compared with less than 30 pmol per gram in normal pituitary glands. The cholecystokinin concentrations were moderately increased in adenomas from another 12 patients, of whom 5 had Cushing's disease and 7 acromegaly with adenomas containing ACTH. The cholecystokinin peptides from the tumors were smaller and less sulfated than cholecystokinin from normal pituitary glands. We conclude that ACTH-producing pituitary cells may also produce an altered form of cholecystokinin.
我们在正常人类腺垂体中发现了少量的胆囊收缩素，因此对87例患有肢端肥大症、库欣病、尼尔森综合征、催乳素瘤或无功能垂体腺瘤的患者的垂体肿瘤进行了检查。与尼尔森综合征相关的5例腺瘤中胆囊收缩素含量增加，其中2例含量极高：每克分别为8281和13453皮摩尔，而正常垂体中每克含量低于30皮摩尔。另外12例患者的腺瘤中胆囊收缩素浓度中度升高，其中5例患有库欣病，7例患有肢端肥大症且腺瘤含有促肾上腺皮质激素。肿瘤中的胆囊收缩素肽比正常垂体中的胆囊收缩素更小且硫酸化程度更低。我们得出结论，产生促肾上腺皮质激素的垂体细胞也可能产生一种改变形式的胆囊收缩素。
