Department of Pharmaceutics, College of Pharmaceutical Sciences, Dayananda Sagar University, Kumaraswamy Layout, Bangalore, Karnataka 560078, India.
J Neurosci Methods. 2019 Jan 1;311:133-146. doi: 10.1016/j.jneumeth.2018.10.015. Epub 2018 Oct 16.
Brain specific drug delivery is one of the most interesting and challenging areas of research. The blood-brain barrier separates the brain from blood and acts as a barrier to protect the brain from microorganisms, neurotoxins and chemical substances. But, the same mechanism poses an obstacle for the entry of many drugs into the brain. Worldwide, approximately 1.5 billion people are suffering from CNS disorders, such as Parkinson's disease, Alzheimer's disease, multiple sclerosis, amyotrophic lateral sclerosis, stroke, HIV-dementia and others. This number indicates the importance of delivering drugs effectively into the brain for treating various brain diseases. The recent advancements in drug targeting, a concept was introduced by Dr. Paul Ehrlich as 'magic bullet' give lot of hopes for delivering drugs specifically to the brain regions to treat brain diseases. This review discusses about the various targeting strategies to deliver drugs into the brain for treating neurological diseases.
脑内递药是最有趣和最具挑战性的研究领域之一。血脑屏障将大脑与血液隔开，充当保护大脑免受微生物、神经毒素和化学物质侵害的屏障。但是，同样的机制也为许多药物进入大脑设置了障碍。全世界约有 15 亿人患有中枢神经系统疾病，如帕金森病、阿尔茨海默病、多发性硬化症、肌萎缩性侧索硬化症、中风、HIV 痴呆症等。这个数字表明，有效地将药物递送到大脑中以治疗各种脑部疾病非常重要。药物靶向的最新进展是由 Paul Ehrlich 博士提出的“魔法子弹”概念，为将药物特异性递送到大脑区域以治疗脑部疾病带来了很多希望。本文综述了将药物递送到大脑以治疗神经疾病的各种靶向策略。
