Department of Pharmaceutics, National Institute of Pharmaceutical Education and Research-Raebareli, New Transit Campus, Bijnor-Sisendi Road, Sarojini Nagar, Near CRPF Base Camp, Lucknow, Uttar Pradesh, 226002, India.
Mol Neurobiol. 2022 Aug;59(8):4806-4824. doi: 10.1007/s12035-022-02882-8. Epub 2022 May 27.
The aim of the present review article is to summarize the role of nanodiamonds in various neurological diseases. We have taken related literature of making this review article from ScienceDirect, springer, Research gate, PubMed, Sci-finder, etc. The current approaches for treating neurological conditions such as glioblastoma includes chemotherapy or combination anti-retro viral therapy for HIV (human immunodeficiency virus) or use of anti-Alzheimer drugs during cognitive impairment. These approaches can provide only symptomatic relief as they do not target the cause of the disease due to their inability to penetrate the blood brain barrier. On long-term use, they may cause CNS toxicity due to accumulation in the brain. So nanodiamonds could prove as a promising approach in the brain targeting of the bioactive and to treat many neurological disorders such as Alzheimer's disease, Parkinson's disease, brain tumor (glioblastoma), HIV, amyotrophic multiple sclerosis, Huntington disease, stroke (cerebrovascular attack), batten disease, schizophrenia, epilepsy, and bacterial infections (encephalitis, sepsis, and meningitis) due to their ability to penetrate the blood-brain barrier and owing to their excellent surface properties, i.e., nano size and high surface area, ease of functionalization, multiple drug binding, and biocompatibility; they can be useful for brain targeted drug delivery with minimal side effects.
本文旨在总结纳米金刚石在各种神经疾病中的作用。我们从 ScienceDirect、springer、Research gate、PubMed、Sci-finder 等相关文献中获取了撰写本文的资料。目前治疗神经疾病的方法包括化疗或联合抗逆转录病毒疗法治疗 HIV（人类免疫缺陷病毒），或在认知障碍期间使用抗阿尔茨海默病药物。这些方法只能提供症状缓解，因为由于它们无法穿透血脑屏障，因此无法针对疾病的原因。长期使用，由于在大脑中积累，它们可能会引起中枢神经系统毒性。因此，纳米金刚石由于其穿透血脑屏障的能力以及能够治疗多种神经疾病，如阿尔茨海默病、帕金森病、脑瘤（胶质母细胞瘤）、HIV、肌萎缩性多发性硬化症、亨廷顿病、中风（脑血管攻击）、巴滕病、精神分裂症、癫痫和细菌性感染（脑炎、败血症和脑膜炎），因此可能成为生物活性物质的脑靶向治疗的一种有前途的方法。由于其具有穿透血脑屏障的能力，以及出色的表面特性，即纳米尺寸和高表面积、易于功能化、可结合多种药物和生物相容性，它们可用于脑靶向药物递送，副作用最小。
