Chair of Chemistry of Biogenic Resources, Technical University of Munich, Campus Straubing for Biotechnology and Sustainability, Schulgasse 16, 94315 Straubing, Germany.
Chair of Chemistry of Biogenic Resources, Technical University of Munich, Campus Straubing for Biotechnology and Sustainability, Schulgasse 16, 94315 Straubing, Germany; Current address: Dr. Ebeling & Assoc. GmbH, Hamburg, Germany.
Curr Opin Chem Biol. 2019 Apr;49:59-66. doi: 10.1016/j.cbpa.2018.10.003. Epub 2018 Oct 16.
Nicotinamide cofactor biomimetics (NCBs) belong to a class of compounds that, as the name suggests, mimic the structures and functions of natural nicotinamide cofactors, namely nicotinamide adenine dinucleotide and nicotinamide adenine dinucleotide phosphate and their corresponding reduced forms. The first set of NCBs was discovered in the 1930s; these were initially used to study the chemical properties of this class of cofactors as well as understand nicotinamide binding of oxidoreductases. Since then, various NCBs, enzymes, and recycling systems have evolved and lately, new NCBs have been developed and used to run biocatalytic reactions.
烟酰胺辅酶类似物（NCBs）属于一类化合物，顾名思义，它们模拟了天然烟酰胺辅酶的结构和功能，即烟酰胺腺嘌呤二核苷酸（NAD）和烟酰胺腺嘌呤二核苷酸磷酸（NADP）及其相应的还原形式。第一组 NCBs 是在 20 世纪 30 年代发现的；这些最初被用于研究这类辅因子的化学性质，并了解氧化还原酶的烟酰胺结合。从那时起，各种 NCBs、酶和回收系统不断发展，最近，又开发了新的 NCBs 并用于进行生物催化反应。
