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一种基于信息提供者的用于神经退行性疾病语言评估的简易问卷。

An Informant-Based Simple Questionnaire for Language Assessment in Neurodegenerative Disorders.

作者信息

Lin Chi-Mo, Hung Guang-Uei, Wei Cheng-Yu, Tzeng Ray-Chang, Chiu Pai-Yi

机构信息

Department of Neurology, Show Chwan Memorial Hospital, Changhua, Taiwan.

Department of Nuclear Medicine, Chang Bing Show Chwan Memorial Hospital, Changhua, Taiwan.

出版信息

Dement Geriatr Cogn Disord. 2018;46(3-4):207-216. doi: 10.1159/000493540. Epub 2018 Oct 18.

DOI:10.1159/000493540
PMID:30336484
Abstract

BACKGROUND/AIMS: Language dysfunction is a crucial feature of brain disorders. This study investigated language dysfunction in patients with dementia with or without parkinsonism by using an informant-based simple questionnaire.

METHODS

Language dysfunction in normal controls (NCs), and patients with Parkinson disease (PD), Parkinson disease dementia (PDD), dementia with Lewy bodies (DLB), or Alzheimer disease (AD) were analyzed and compared.

RESULTS

A total of 1,662 individuals were studied: 285 NCs, 157 PD patients, 161 PDD patients, 248 DLB patients, and 811 AD patients. Patients with PD displayed higher frequency of language dysfunction in several language domains than NC. Patients with PDD and DLB showed higher frequency of language dysfunction in most of the language domains than those with AD. A composite score of our simple questionnaire was comparable with the score for the language domain of the Cognitive Abilities Screening Instrument (CASI) in different stages of dementia due to Lewy body diseases or not.

CONCLUSION

Our study showed that the informant-based simple questionnaire is a practical screening tool and is comparable with the language subscale of CASI. This tool can be applied in clinical practice and in the registration platform for rapid language dysfunction screening.

摘要

背景/目的：语言功能障碍是脑部疾病的一个关键特征。本研究通过使用基于 informant 的简单问卷，调查了患有或未患有帕金森症的痴呆患者的语言功能障碍。

方法

分析并比较了正常对照组（NCs）、帕金森病（PD）患者、帕金森病痴呆（PDD）患者、路易体痴呆（DLB）患者或阿尔茨海默病（AD）患者的语言功能障碍情况。

结果

共研究了 1662 人：285 名 NCs、157 名 PD 患者、161 名 PDD 患者、248 名 DLB 患者和 811 名 AD 患者。PD 患者在几个语言领域的语言功能障碍发生率高于 NCs。PDD 和 DLB 患者在大多数语言领域的语言功能障碍发生率高于 AD 患者。我们简单问卷的综合得分与认知能力筛查工具（CASI）语言领域在路易体疾病导致或未导致的不同痴呆阶段的得分相当。

结论

我们的研究表明，基于 informant 的简单问卷是一种实用的筛查工具，与 CASI 的语言子量表相当。该工具可应用于临床实践和注册平台，用于快速筛查语言功能障碍。

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