急性淋巴细胞白血病患者中由蜡样芽孢杆菌引起的快速进展性致命感染
Rapidly Progressive, Fata Infection Caused by Bacillus Cereus in a Patient with Acute Lymphoblastic Leukemia.
作者信息
Zhang Jing-Wen, Zeng Yun-Xin, Liang Jia-Yin, Zhang Ling, Zhao Xin-Bao, Pan Jian-Hua, Xiao Ruo-Zhi
出版信息
Clin Lab. 2018 Oct 1;64(10):1761-1764. doi: 10.7754/Clin.Lab.2018.180528.
BACKGROUND
We herein report a fatal case of fulminant septicemia caused by Bacillus cereus in a 49-year-old female with T-cell acute lymphoblastic leukemia receiving chemotherapy.
METHODS
Her two blood culture sets were positive for Gram-positive, rod-shaped bacterium. Bacillus cereus was identified by high-throughput MALDI-TOF mass spectrometry and 16S ribosomal RNA gene sequencing.
RESULTS
The patient died within 12 hours from the onset of B cereus infection.
CONCLUSIONS
Patients with acute leukemia presented with fever and unexplained multiple organ lesions, especially accompanied by CNS symptoms, should alert to the possibility of Bacillus cereus infection.
背景
我们在此报告一例由蜡样芽孢杆菌引起的暴发性败血症致死病例，患者为一名49岁接受化疗的T细胞急性淋巴细胞白血病女性。
方法
她的两组血培养结果显示革兰氏阳性杆状细菌呈阳性。通过高通量基质辅助激光解吸电离飞行时间质谱和16S核糖体RNA基因测序鉴定出蜡样芽孢杆菌。
结果
患者在蜡样芽孢杆菌感染发病后12小时内死亡。
结论
急性白血病患者出现发热和不明原因的多器官损害，尤其是伴有中枢神经系统症状时，应警惕蜡样芽孢杆菌感染的可能性。
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