Key Laboratory of Resource Biology and Modern Biotechnology in Western China, Ministry of Education, Northwest University, No. 229 TaiBai North Road, Xi'an 710069, China.
Shaanxi Traditional Chinese Medicine Innovation Engineering Technology Research Center, No. 229 Taibai North Road, Xi'an 710069, China.
Int J Mol Sci. 2018 Oct 17;19(10):3210. doi: 10.3390/ijms19103210.
Senna and its main components sennosides are well-known effective laxative drugs and are used in the treatment of intestinal constipation in the world. Their potential side effects have attracted more attention in clinics but have little scientific justification. In this study, senna extract (SE), sennosides (SS), and sennoside A (SA) were prepared and used to generate diarrhea rats. The diarrhea rats were investigated with behaviors, clinical signs, organ index, pathological examination, and gene expression on multiple aquaporins () including , , , , , , , , , and . Using qRT-PCR, the expression profiles were constructed for six organs including colon, kidney, liver, spleen, lung, and stomach. The alteration profiles were characterized and was performed with Principle Component Analysis (PCA). The SE treatments on the rats resulted in a significant body weight loss ( < 0.001), significant increases ( < 0.001) on the kidney index (27.72%) and liver index (42.55%), and distinguished changes with up-regulation on expressions in the kidneys and livers. The SS treatments showed prominent laxative actions and down regulation on expression in the colons. The study results indicated that the SE had more influence/toxicity on the kidneys and livers. The SS showed more powerful actions on the colons. We suggest that the caution should be particularly exercised in the patients with kidney and liver diseases when chronic using senna-based products.
番泻叶及其主要成分番泻苷是众所周知的有效泻药，用于治疗世界各地的肠道便秘。它们的潜在副作用在临床上引起了更多关注，但缺乏科学依据。在这项研究中，制备了番泻叶提取物（SE）、番泻苷（SS）和番泻苷 A（SA），并用于生成腹泻大鼠。用行为、临床症状、器官指数、病理检查和多个水通道蛋白（AQP）的基因表达（包括 、 、 、 、 、 、 、 和 ）研究腹泻大鼠。使用 qRT-PCR 构建了包括结肠、肾脏、肝脏、脾脏、肺和胃在内的六个器官的 表达谱。对 改变谱进行了特征描述，并进行了主成分分析（PCA）。SE 处理大鼠导致显著的体重减轻（<0.001），肾脏指数（27.72%）和肝脏指数（42.55%）显著增加（<0.001），并在肾脏和肝脏中表现出上调的 表达变化。SS 处理表现出明显的通便作用，并下调结肠中的 表达。研究结果表明，SE 对肾脏和肝脏的影响更大。SS 对结肠的作用更强。我们建议，慢性使用含番泻叶产品的患者应特别注意肾脏和肝脏疾病。
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