白三烯的胃效应。

Gastric effects of leukotrienes.

作者信息

Guslandi M

出版信息

Prostaglandins Leukot Med. 1987 Mar;26(3):203-8. doi: 10.1016/0262-1746(87)90030-8.

Abstract

The effects of leukotrienes on gastric functions have been outlined by recent experimental and clinical studies. Leukotrienes were found to stimulate pepsin secretion, to reduce mucosal blood flow and to interfere with gastric emptying. Lipoxygenase products appear to impair gastric mucosal integrity and to exacerbate the damaging effects of noxious agents such as absolute ethanol. Drugs acting as leukotriene inhibitors may have a place in the future as anti-ulcer agents.

摘要

近期的实验和临床研究已概述了白三烯对胃功能的影响。发现白三烯可刺激胃蛋白酶分泌、减少黏膜血流并干扰胃排空。脂氧合酶产物似乎会损害胃黏膜完整性，并加剧诸如无水乙醇等有害物质的破坏作用。作为白三烯抑制剂的药物未来可能会作为抗溃疡药物占有一席之地。