白三烯刺激离体胃壁细胞分泌胃酸。

Leukotrienes stimulate acid secretion from isolated gastric parietal cells.

作者信息

Magous R, Bali J P, Rossi J C, Girard J P

出版信息

Biochem Biophys Res Commun. 1983 Aug 12;114(3):897-900. doi: 10.1016/0006-291x(83)90644-7.

Abstract

Leukotrienes LTC4 and LTD4 display contractile effect on the stomach. The stimulation of acid secretion by LTC4, LTD4 and LTE4 was evidenced on a crude isolated cell preparation from rabbit gastric mucosa using the (14C)aminopyrine accumulation method. LTs were in the same order of potency. No potentiation with histamine, carbachol or IBMX was observed suggesting a specific mechanism for LTs on parietal cell.

摘要

白三烯LTC4和LTD4对胃部有收缩作用。利用（14C）氨基比林蓄积法，在从兔胃黏膜分离出的粗制细胞制剂上证实了LTC4、LTD4和LTE4对胃酸分泌的刺激作用。白三烯的效力顺序相同。未观察到与组胺、卡巴胆碱或异丁基甲基黄嘌呤有增强作用，提示白三烯对壁细胞有特定作用机制。