慢性丙咪嗪和电休克治疗对用慢性利血平或6-羟基多巴胺预处理的大鼠皮质膜[3H]DADLE结合的影响。
The effect of chronic imipramine and electroconvulsive shock treatment on [3H]DADLE binding to cortical membranes of rats pretreated with chronic reserpine or 6-hydroxydopamine.
作者信息
Antkiewicz-Michaluk L, Michaluk J, Rokosz-Pelc A, Marona-Lewicka D, Vetulani J
出版信息
Pharmacol Biochem Behav. 1987 Feb;26(2):203-6. doi: 10.1016/0091-3057(87)90105-5.
PMID:3033693
Abstract
Repetitive electroconvulsive shock treatment (for 8 days) or chronic administration of imipramine (10 mg/kg/day IP for 14 or 21 days) elevated the density of opioid delta receptors in the cerebral cortex of the rat. Electroconvulsive shock treatment produced a similar effect in rats treated subchronically with reserpine or receiving intraventricularly 6-hydroxydopamine, but these manipulations of central catecholamines prevented the action of imipramine.
摘要
重复电休克治疗（持续8天）或长期给予丙咪嗪（腹腔注射，10毫克/千克/天，持续14或21天）可提高大鼠大脑皮质中阿片δ受体的密度。电休克治疗对长期接受利血平治疗或脑室内注射6-羟基多巴胺的大鼠产生了类似的效果，但这些对中枢儿茶酚胺的处理阻止了丙咪嗪的作用。
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