Neurogastroenterology and Motility Unit, Department of Pediatric Gastroenterology, Great Ormond Street Hospital, London WC1N 3JH, UK; Department of Clinical Medicine and Surgery, 'Federico II' University of Naples, Via Pansini 5, Naples 80131, Italy.
Neurogastroenterology and Motility Unit, Department of Pediatric Gastroenterology, Great Ormond Street Hospital, London WC1N 3JH, UK.
Gastroenterol Clin North Am. 2018 Dec;47(4):877-894. doi: 10.1016/j.gtc.2018.07.011. Epub 2018 Sep 28.
The bewildering complexity of the enteric nervous system makes it susceptible to develop a wide array of motility disorders, collectively called enteric neuropathies. These gastrointestinal conditions are among the most challenging to manage, mainly given poor characterization of their etiopathophysiology and outcomes. Not surprisingly, therefore, targeted or curative therapies for enteric neuropathies are lacking and management is largely symptomatic. Nonetheless, recent advances in neurogastroenterology have witnessed improvements in established strategies, such as intestinal transplantation and the emergence of new treatments including novel drugs, electrical pacing, and manipulation of fecal microbiota, as well as stem cell and gene therapy.
肠神经系统的错综复杂使其容易出现多种运动障碍，统称为肠神经病。这些胃肠道疾病是最难治疗的，主要是因为其病因发病机制和结果的特征描述较差。因此，不出所料，针对肠神经病的靶向或治愈疗法是缺乏的，治疗主要是对症治疗。尽管如此，神经胃肠病学的最新进展见证了既定策略的改进，例如肠移植和新治疗方法的出现，包括新型药物、电起搏以及粪便微生物群的操纵，以及干细胞和基因治疗。
