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[立体定向放射治疗I期非小细胞肺癌后辐射诱导的肺毒性预测因素]

[Radiation-induced lung toxicity predictors after stereotactic radiation therapy for non-small cell lung carcinoma stage I].

作者信息

Menoux I, Le Fèvre C, Noël G, Antoni D

机构信息

Département universitaire de radiothérapie, centre Paul-Strauss, 3, rue de la Porte-de-l'Hôpital, BP 42, 67065 Strasbourg cedex, France.

Département universitaire de radiothérapie, centre Paul-Strauss, 3, rue de la Porte-de-l'Hôpital, BP 42, 67065 Strasbourg cedex, France.

出版信息

Cancer Radiother. 2018 Dec;22(8):826-838. doi: 10.1016/j.canrad.2017.12.007. Epub 2018 Oct 15.

Abstract

In case of refusal or contraindication for surgical management of a stage I non-small cell lung carcinoma, the validated alternative therapy is stereotactic irradiation. This technique reaches an equivalent tumour control rate than surgery and significantly higher than conventional radiotherapy. One of the dreaded complications is radiation induced lung toxicity (radiation pneumonitis and lung fibrosis), especially when it is symptomatic, occurring in about 10 % of cases. This article is a literature review of this complication's predictive factors.

摘要

对于I期非小细胞肺癌患者,如果拒绝手术治疗或存在手术禁忌证,经验证的替代治疗方法是立体定向放射治疗。该技术的肿瘤控制率与手术相当,且显著高于传统放疗。令人担忧的并发症之一是放射性肺毒性(放射性肺炎和肺纤维化),尤其是出现症状时,约10%的病例会发生。本文是关于该并发症预测因素的文献综述。

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