Mao Zhenkun, Chen Zilin
Key Laboratory of Combinatorial Biosynthesis and Drug Discovery, Ministry of Education, Wuhan University School of Pharmaceutical Sciences, Wuhan 430071, China.
State Key Laboratory of Transducer Technology, Chinese Academy of Sciences, Beijing 10080, China.
J Pharm Anal. 2019 Aug;9(4):227-237. doi: 10.1016/j.jpha.2019.05.002. Epub 2019 May 11.
Capillary electrochromatography (CEC) is a micro-scale separation technique which is a hybrid between capillary electrophoresis (CE) and liquid chromatography (LC). CEC can be performed in packed, monolithic and open-tubular columns. In recent three years (from 2016 to 2018), enormous attention for CEC has been the development of novel stationary phases. This review mainly covers the development of novel stationary phases for open-tubular and monolithic columns. In particular, some biomaterials attracted increasing interest. There are no significant breakthroughs in technology and principles in CEC. The typical CEC applications, especially chiral separations are described.
毛细管电色谱（CEC）是一种微观分离技术，它是毛细管电泳（CE）和液相色谱（LC）的结合体。CEC可以在填充柱、整体柱和开管柱中进行。在最近三年（2016年至2018年），对CEC的极大关注在于新型固定相的开发。本综述主要涵盖开管柱和整体柱新型固定相的发展。特别是，一些生物材料引起了越来越多的关注。CEC在技术和原理方面没有重大突破。文中描述了CEC的典型应用，尤其是手性分离。
