T细胞淋巴瘤中的非典型表面标志物特征

ATYPICAL SURFACE MAKER CHARACTERISTICS IN A T-cell lymphoma.

作者信息

Janossy G, McVerry B A, Goldstone A H, Souhami R L, Cawley J C, Thompson D S

出版信息

Scand J Haematol. 1977 Oct;19(4):411-5. doi: 10.1111/j.1600-0609.1977.tb01493.x.

DOI:10.1111/j.1600-0609.1977.tb01493.x

Abstract

A case of T-cell lymphoma with an unusual phenotype is described. The majority of malignant tumour cells did not form E-rosettes, and lacked surface immunoglobulin but reacted with an antiserum to T cells and thymocytes. Localised acid phosphatase and non-specific alpha naphthol acid esterase activities and a prominent, convoluted, nuclear pattern in some neoplastic cells also supported the T cell derivation. The results demonstrate the importance of using a panel of markers for identification of the cellular derivation of some lymphomas.

摘要

本文描述了一例具有异常表型的T细胞淋巴瘤。大多数恶性肿瘤细胞不形成E花环，缺乏表面免疫球蛋白，但与抗T细胞和胸腺细胞抗血清发生反应。局部酸性磷酸酶和非特异性α萘酚酸酯酶活性以及一些肿瘤细胞中突出的、卷曲的核型也支持其T细胞来源。结果表明，使用一组标志物来鉴定某些淋巴瘤的细胞来源具有重要意义。