Wolfe N, Cohen B M, Gelenberg A J
Psychiatry Res. 1987 Feb;20(2):107-16. doi: 10.1016/0165-1781(87)90003-5.
Specific binding to alpha 2-adrenergic receptors was studied in the platelets of 31 patients with major depressive disorder and 18 normal controls using the selective antagonist 3H-yohimbine. Receptor density for depressed patients (Bmax = 88 +/- SD 45.1 fmoles/mg) was not significantly lower than that for controls (124 +/- SD 78.1 fmoles/mg). The affinity of the receptor for yohimbine was significantly greater in depressed patients (Kd = 1.05 +/- SD 0.47 nM) than in controls (Kd = 1.47 +/- SD 0.63 nM). This is consistent with the hypothesis of increased alpha 2-adrenergic receptor sensitivity in depressive disorders. Past studies of alpha 2-adrenergic receptors on platelets are reviewed, and the importance of designing studies with sufficient statistical power is discussed.
使用选择性拮抗剂3H-育亨宾，对31例重度抑郁症患者和18名正常对照者的血小板中α2-肾上腺素能受体的特异性结合进行了研究。抑郁症患者的受体密度（Bmax = 88±标准差45.1飞摩尔/毫克）并不显著低于对照组（124±标准差78.1飞摩尔/毫克）。抑郁症患者中受体对育亨宾的亲和力（Kd = 1.05±标准差0.47纳摩尔）显著高于对照组（Kd = 1.47±标准差0.63纳摩尔）。这与抑郁症中α2-肾上腺素能受体敏感性增加的假说一致。回顾了以往关于血小板上α2-肾上腺素能受体的研究，并讨论了设计具有足够统计效力的研究的重要性。
