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一例炎症性线状疣状表皮痣经布罗达单抗治疗成功。

A case of inflammatory linear verrucous epidermal nevus successfully treated with Brodalumab.

机构信息

Division of Dermatology, University of Calgary, Calgary, Alberta, Canada.

Department of Pathology and Laboratory Medicine, University of Calgary, Calgary, Alberta, Canada.

出版信息

Pediatr Dermatol. 2022 Sep;39(5):757-760. doi: 10.1111/pde.15058. Epub 2022 Jun 3.

Abstract

Inflammatory linear verrucous epidermal nevus (ILVEN) is a rare type of epidermal nevus, commonly arising in childhood. We present a case of a 13-year-old female with Blaschkoid psoriasiform plaques extending from her left foot to the scalp, sparing the right side of the body. While treatment options historically show variable success, we trialed an IL-17a receptor inhibitor as studies have shown increased levels of IL-17 receptor expression in ILVEN keratinocytes. At both 3 and 6 months after treatment initiation there was found to be significant improvement. We propose brodalumab as an effective treatment option for widespread ILVEN.

摘要

炎症性线状疣状表皮痣(ILVEN)是一种罕见的表皮痣,通常在儿童时期发病。我们报告了一例 13 岁女性患者,其 Blaschkoid 银屑病样斑块从左脚延伸至头皮,身体右侧未受累。虽然既往的治疗方法显示出不同程度的疗效,但我们尝试使用 IL-17a 受体抑制剂,因为研究表明 ILVEN 角质形成细胞中 IL-17 受体表达增加。治疗开始后 3 个月和 6 个月时均发现有显著改善。我们提出布罗达卢单抗是治疗广泛 ILVEN 的有效治疗选择。

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