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本文引用的文献

1
Metabolic labeling in middle-down proteomics allows for investigation of the dynamics of the histone code.中向蛋白质组学中的代谢标记可用于研究组蛋白密码的动态变化。
Epigenetics Chromatin. 2017 Jul 6;10(1):34. doi: 10.1186/s13072-017-0139-z.
2
Post-translational modifications are key players of the Legionella pneumophila infection strategy.翻译后修饰是嗜肺军团菌感染策略的关键因素。
Front Microbiol. 2015 Feb 10;6:87. doi: 10.3389/fmicb.2015.00087. eCollection 2015.
3
Chem-seq permits identification of genomic targets of drugs against androgen receptor regulation selected by functional phenotypic screens.化学生物学测序允许通过功能表型筛选选择的针对雄激素受体调控的药物的基因组靶标鉴定。
Proc Natl Acad Sci U S A. 2014 Jun 24;111(25):9235-40. doi: 10.1073/pnas.1404303111. Epub 2014 Jun 13.
4
Legionella pneumophila effector RomA uniquely modifies host chromatin to repress gene expression and promote intracellular bacterial replication.嗜肺军团菌效应蛋白 RomA 特异性修饰宿主染色质，抑制基因表达，促进细菌在细胞内的复制。
Cell Host Microbe. 2013 Apr 17;13(4):395-405. doi: 10.1016/j.chom.2013.03.004.
5
Identification of combinatorial patterns of post-translational modifications on individual histones in the mouse brain.鉴定小鼠脑内组蛋白上翻译后修饰的组合模式。
PLoS One. 2012;7(5):e36980. doi: 10.1371/journal.pone.0036980. Epub 2012 May 31.
6
Quantitative mass spectrometry of histones H3.2 and H3.3 in Suz12-deficient mouse embryonic stem cells reveals distinct, dynamic post-translational modifications at Lys-27 and Lys-36.组蛋白 H3.2 和 H3.3 在 Suz12 缺失的小鼠胚胎干细胞中的定量质谱分析揭示了 Lys-27 和 Lys-36 处独特且动态的翻译后修饰。
Mol Cell Proteomics. 2010 May;9(5):838-50. doi: 10.1074/mcp.M900489-MCP200. Epub 2010 Feb 11.
7
Analysis of dynamic changes in post-translational modifications of human histones during cell cycle by mass spectrometry.通过质谱分析细胞周期中人类组蛋白翻译后修饰的动态变化。
Mol Cell Proteomics. 2007 Nov;6(11):1917-32. doi: 10.1074/mcp.M700070-MCP200. Epub 2007 Jul 20.
8
Organismal differences in post-translational modifications in histones H3 and H4.组蛋白H3和H4翻译后修饰中的生物体差异。
J Biol Chem. 2007 Mar 9;282(10):7641-55. doi: 10.1074/jbc.M607900200. Epub 2006 Dec 28.
9
Reversal of histone lysine trimethylation by the JMJD2 family of histone demethylases.组蛋白去甲基化酶JMJD2家族对组蛋白赖氨酸三甲基化的逆转作用。
Cell. 2006 May 5;125(3):467-81. doi: 10.1016/j.cell.2006.03.028. Epub 2006 Apr 6.
10
Histone H3.3 is enriched in covalent modifications associated with active chromatin.组蛋白H3.3富含与活性染色质相关的共价修饰。
Proc Natl Acad Sci U S A. 2004 Feb 10;101(6):1525-30. doi: 10.1073/pnas.0308092100. Epub 2004 Jan 19.

H3K14me3 genomic distributions and its regulation by KDM4 family demethylases.

作者信息

Zhao Bin, Xu Wenqi, Rong Bowen, Chen Guoyu, Ye Xuanjia, Dai Ruofei, Li Wenjing, Chen Jiajia, Cai Jiajun, Song Lei, Luo Zhao-Qing, Zeng Rong, Shi Yang, Han Jing-Dong J, Lan Fei

机构信息

Liver Cancer Institute, Zhongshan Hospital, Fudan University, Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education, Key Laboratory of Epigenetics and Metabolism, Ministry of Science and Technology, and Institutes of Biomedical Sciences, Fudan University, Shanghai, 200032, China.

Key Laboratory of Computational Biology, CAS Center for Excellence in Molecular Cell Science, Collaborative Innovation Center for Genetics and Developmental Biology, Chinese Academy of Sciences-Max Planck Partner Institute for Computational Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yue Yang Road, Shanghai, 200031, China.

出版信息

Cell Res. 2018 Nov;28(11):1118-1120. doi: 10.1038/s41422-018-0095-6. Epub 2018 Oct 18.

DOI:10.1038/s41422-018-0095-6
PMID:30337684
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6218439/
Abstract
摘要