Smith B S, Wright H, Brown K G
Vet Rec. 1987 Feb 28;120(9):199-201. doi: 10.1136/vr.120.9.199.
Pregnant ewes were injected intramuscularly with 300,000 iu of vitamin D3 in a water miscible vehicle either 10, seven or four weeks before the expected lambing date and the effects on plasma concentrations of 25-hydroxyvitamin D3 were monitored. The concentrations increased quickly and remained high at parturition but at no time were they outside the normal physiological range. The concentrations in the plasma of the newborn lambs were higher than in uninjected controls and were well correlated with the concentrations in their mothers. Dosing pregnant ewes with 300,000 iu of vitamin D3 in a rapidly available form, approximately two months before lambing, provided a safe means of increasing the vitamin D status of the ewe and the newborn lamb by preventing the seasonally low concentrations of 25-hydroxyvitamin D3.
在预计产羔日期前10周、7周或4周，给怀孕母羊肌肉注射30万国际单位溶于水混溶载体的维生素D3，并监测其对血浆25 - 羟基维生素D3浓度的影响。浓度迅速升高，分娩时保持在较高水平，但未超出正常生理范围。新生羔羊血浆中的浓度高于未注射的对照组，且与它们母亲的浓度密切相关。在产羔前约两个月，以快速可用的形式给怀孕母羊注射30万国际单位的维生素D3，通过防止25 - 羟基维生素D3季节性低浓度，提供了一种提高母羊和新生羔羊维生素D水平的安全方法。
