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基于纳米纤维的糖尿病治疗系统。

Nanofiber-based systems intended for diabetes.

机构信息

Nano Drug Delivery Research Center, Health Technology Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran.

Research and Development Team, Evolution Wound Dressing (EWD) Startup Co., Tehran, Iran.

出版信息

J Nanobiotechnology. 2021 Oct 12;19(1):317. doi: 10.1186/s12951-021-01065-2.

DOI:10.1186/s12951-021-01065-2
PMID:34641920
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8513238/
Abstract

Diabetic mellitus (DM) is the most communal metabolic disease resulting from a defect in insulin secretion, causing hyperglycemia by promoting the progressive destruction of pancreatic β cells. This autoimmune disease causes many severe disorders leading to organ failure, lower extremity amputations, and ultimately death. Modern delivery systems e.g., nanofiber (NF)-based systems fabricated by natural and synthetic or both materials to deliver therapeutics agents and cells, could be the harbinger of a new era to obviate DM complications. Such delivery systems can effectively deliver macromolecules (insulin) and small molecules. Besides, NF scaffolds can provide an ideal microenvironment to cell therapy for pancreatic β cell transplantation and pancreatic tissue engineering. Numerous studies indicated the potential usage of therapeutics/cells-incorporated NF mats to proliferate/regenerate/remodeling the structural and functional properties of diabetic skin ulcers. Thus, we intended to discuss the aforementioned features of the NF system for DM complications in detail.

摘要

糖尿病（DM）是最常见的代谢性疾病，源于胰岛素分泌缺陷，通过促进胰腺β细胞的渐进性破坏导致高血糖。这种自身免疫性疾病会导致许多严重的并发症，导致器官衰竭、下肢截肢，最终导致死亡。现代传递系统，例如基于纳米纤维（NF）的系统，由天然和合成材料或两者的混合物制造，用于传递治疗剂和细胞，可能预示着一个新时代的到来，可以避免 DM 并发症。这种传递系统可以有效地传递大分子（胰岛素）和小分子。此外，NF 支架可以为胰腺β细胞移植和胰腺组织工程的细胞治疗提供理想的微环境。许多研究表明，含有治疗剂/细胞的 NF 垫在促进/再生/重塑糖尿病皮肤溃疡的结构和功能特性方面具有潜在的用途。因此，我们旨在详细讨论 NF 系统在 DM 并发症方面的上述特征。

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