Kul'chitskiĭ O K
Vopr Med Khim. 1987 Jan-Feb;33(1):19-21.
Age-dependent differences were found in patterns of rat liver adenylate cyclase system in response to hepatectomy-induced proliferation. After hepatectomy a decrease in basic activity of adenylate cyclase and in content of cAMP were observed only in adult animals. At the same time, the epinephrine-stimulated enzymatic activity was decreased in old hepatectomized rats as compared with intact animals. These alterations in regulatory activity of the adenylate cyclase system appear to affect the intensity of DNA biosynthesis and the functional activity of regenerating liver tissue of old rats.
在大鼠肝脏腺苷酸环化酶系统对肝切除诱导的增殖反应模式中发现了年龄依赖性差异。肝切除后，仅在成年动物中观察到腺苷酸环化酶的基础活性和cAMP含量降低。同时，与完整动物相比，老年肝切除大鼠中肾上腺素刺激的酶活性降低。腺苷酸环化酶系统调节活性的这些改变似乎会影响老年大鼠再生肝组织中DNA生物合成的强度和功能活性。
