Davletov E G, Karelin A A, Kamilov F Kh
Vopr Med Khim. 1988 May-Jun;34(3):120-4.
Thermal trauma caused a distinct increase in content of cAMP and cGMP in blood as well as in liver and kidney tissues of one-month-old rats within the first week after burns. Alterations, which depend on the step of burn development, were found in basal and adrenaline, fluoride-stimulated activities of adenylate cyclase in liver and kidney tissues of experimental animals. Activity of phosphodiesterase was altered only slightly under similar experimental conditions while pronounced decrease in the enzymatic activity was observed in rat liver tissue within 6 hrs after burns.
热创伤导致1月龄大鼠在烧伤后的第一周内，血液以及肝脏和肾脏组织中的环磷酸腺苷（cAMP）和环磷酸鸟苷（cGMP）含量显著增加。在实验动物的肝脏和肾脏组织中，发现腺苷酸环化酶的基础活性以及肾上腺素、氟化物刺激的活性存在取决于烧伤发展阶段的变化。在类似实验条件下，磷酸二酯酶的活性仅略有改变，而在烧伤后6小时内，大鼠肝脏组织中的酶活性出现明显下降。
