Frol'kis V V, Kul'chitskiĭ O K, Iasechko A V
Vopr Med Khim. 1988 May-Jun;34(3):48-51.
The denervation-induced changes of cyclic nucleotide concentrations adenylate cyclase activity and resting membrane potential were studied in gastrocnemius muscle of adult and old rats. Under conditions of denervation alterations in resting membrane potential and in adrenaline-stimulated adenylate cyclase activity had a biphasic character in the muscle studied: resting membrane potential was increased and the adenylate cyclase activity was decreased following 30 min denervation, while the opposite effect was observed after 2 weeks denervation. The denervation did not alter cGMP concentration. In old animals more pronounced changes of cAMP level were found in denervated gastrocnemius muscle.
研究了去神经支配对成年和老年大鼠腓肠肌中环状核苷酸浓度、腺苷酸环化酶活性和静息膜电位的影响。在去神经支配的情况下，所研究肌肉的静息膜电位和肾上腺素刺激的腺苷酸环化酶活性的改变具有双相性：去神经支配30分钟后，静息膜电位升高，腺苷酸环化酶活性降低，而去神经支配2周后则观察到相反的效果。去神经支配未改变环鸟苷酸（cGMP）浓度。在老年动物中，去神经支配的腓肠肌中发现环磷酸腺苷（cAMP）水平的变化更为明显。
