Quidel Sebastián, Gómez Evelyn, Bravo-Soto Gonzalo, Ortigoza Ángela
Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile; Proyecto Epistemonikos, Santiago, Chile.
Proyecto Epistemonikos, Santiago, Chile; Centro Evidencia UC, Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile.
Medwave. 2018 Oct 3;18(6):e7261. doi: 10.5867/medwave.2018.06.7260.
The common cold causes great morbidity throughout the world and there are no effective therapeutic agents against it. There is a belief that consuming vitamin C during a cold episode would help reduce duration and severity of symptoms. However, there is controversy about this claim.
To answer this question we used Epistemonikos, the largest database of systematic reviews in health, which is maintained by screening multiple information sources, including MEDLINE, EMBASE, Cochrane, among others. We extracted data from the systematic reviews, reanalyzed data of primary studies, conducted a meta-analysis and generated a summary of findings table using the GRADE approach.
We identified four systematic reviews that included eight primary studies overall, of which seven were randomized trials. We concluded vitamin C has minimal or no impact on the duration of common cold or in the number of days at home or out of work.
普通感冒在全球范围内导致了很高的发病率，并且没有有效的治疗药物。有一种观点认为，在感冒期间服用维生素C有助于缩短症状持续时间并减轻症状严重程度。然而，这一说法存在争议。
为回答这个问题，我们使用了Epistemonikos，这是健康领域最大的系统评价数据库，它通过筛选多个信息来源来维护，包括MEDLINE、EMBASE、Cochrane等。我们从系统评价中提取数据，重新分析了原始研究的数据，进行了荟萃分析，并使用GRADE方法生成了结果总结表。
我们确定了四项系统评价，总共包括八项原始研究，其中七项是随机试验。我们得出结论，维生素C对普通感冒的持续时间或在家或缺勤天数几乎没有影响。
