Department of Immunopathology, Faculty of Medicine, Medical University of Lodz, Lodz, Poland.
BMC Fam Pract. 2021 Oct 30;22(1):216. doi: 10.1186/s12875-021-01561-2.
Common cold is a frequent illness in northern hemisphere between late autumn and early spring. Patients suffering from it frequently turn to pharmacists instead of physicians in order to receive medical advice and treatment. We studied its treatment advised by pharmacists in Poland, as well as evidence for the efficacy of their recommendations by utilizing a self-developed questionnaire and a study of existing literature.
The data were collected by 27 pharmacists who worked in four large network community pharmacies in Lodz, Poland. The study took place from December 2019 to February 2020. Data were recorded only if the patient asked for pharmacy counselling for over-the counter (OTC) products due to common cold self-diagnosis and a product was sold. Pharmacists' recommendations were compared with the results of a literature review of best evidence to determine appropriateness of the pharmacists' decisions.
In four out of five cases the pharmacists recommended products contained paracetamol. In addition, in one out of three patient encounters they advised nasal decongestant, inosines and/or OTC mucolytics. There was a significant relationship between fever and recommendation frequency of some analgesics, inosines, mucolytics and sore throat products (OR > 1, p < 0.05); rhinorrhea and recommendation frequency of paracetamol, inosines, anti-histamines and alpha-mimetics (OR > 1, p < 0.05); cough and recommendation frequency of paracetamol, inosines, mucolytics and sore throat products (OR > 1, p < 0.05); and fatigue and recommendation frequency of paracetamol, acetylsalicylic acid, inosines and sore throat products (OR > 1, p < 0.05). The pharmacist recommendations were based on patients' symptoms, product price, pharmaceutical company promotion and the financial incentive. In many cases their recommendations were not in line with current best practice recommendations.
Our study suggests that the most common rationale for pharmacist recommendation on anti-common cold treatment was to take a "shotgun" approach. Pharmacists commonly made recommendations for products that lack strong evidence for efficacy (i.e. anti-viral agents) and are potentially unnecessary, based on presentation of the symptom. Reasons for this situation include lack of training, lack of time to evaluate the patient, lack of awareness of evidence as well as drug company marketing and financial incentives (i.e. fulfilling sale plans and target sale bonuses).
The study was a non-interventional, observational research trial. The study registration was not required.
普通感冒是北半球晚秋至早春期间的常见疾病。患者常向药剂师而不是医生寻求医疗建议和治疗。我们利用自行设计的问卷和对现有文献的研究,研究了波兰药剂师建议的治疗方法,并评估了他们的建议的疗效证据。
数据由在波兰罗兹的四家大型网络社区药房工作的 27 名药剂师收集。研究于 2019 年 12 月至 2020 年 2 月进行。只有在患者因自我诊断为普通感冒而向药店咨询非处方 (OTC) 产品并销售产品时,才记录数据。将药剂师的建议与最佳证据文献综述的结果进行比较,以确定药剂师决策的适当性。
在五种情况下有四种情况下,药剂师建议使用含有对乙酰氨基酚的产品。此外,在三分之一的患者就诊中,他们建议使用鼻腔减充血剂、肌苷和/或 OTC 黏液溶解剂。在发热和某些镇痛药、肌苷、黏液溶解剂和咽喉痛产品推荐频率之间存在显著关系(OR>1,p<0.05);在流鼻涕和对乙酰氨基酚、肌苷、抗组胺药和α-拟交感神经药推荐频率之间存在显著关系(OR>1,p<0.05);在咳嗽和对乙酰氨基酚、肌苷、黏液溶解剂和咽喉痛产品推荐频率之间存在显著关系(OR>1,p<0.05);在疲劳和对乙酰氨基酚、乙酰水杨酸、肌苷和咽喉痛产品推荐频率之间存在显著关系(OR>1,p<0.05)。药剂师的建议是基于患者的症状、产品价格、制药公司的推广和经济激励。在许多情况下,他们的建议与当前最佳实践建议不符。
我们的研究表明,药剂师推荐抗普通感冒治疗的最常见依据是采取“霰弹枪”方法。药剂师通常会推荐缺乏疗效证据(即抗病毒药物)且可能不必要的产品,这是基于症状的表现。这种情况的原因包括缺乏培训、评估患者的时间不足、对证据的认识不足以及药物公司的营销和经济激励(即完成销售计划和实现销售奖金目标)。
该研究是非干预性、观察性研究试验。不需要研究注册。