Kozasa K, Nakai Y
Acta Anat (Basel). 1987;128(3):243-9. doi: 10.1159/000146346.
The synaptic relationship between catecholamine terminals and adrenocorticotropic hormone (ACTH)-containing neurons in the arcuate nucleus (AN) of the rat hypothalamus was investigated by electron microscopy, using ACTH immunocytochemistry combined with autoradiography after 3H-dopamine (3H-DA) injection or 5-hydroxydopamine (5-OHDA) uptake in the same tissue section. ACTH-like (ACTH-LI) immunoreactive nerve cell bodies and fibers received synaptic inputs by axon terminals labeled with 3H-DA or 5-OHDA in the AN. This suggests that catecholaminergic neurons, at least DA- and 5-OHDA-containing neurons, may play an important role in the regulation of ACTH secretion or other functions of ACTH neurons via synapses in the AN of the rat hypothalamus.
采用电子显微镜技术，通过在同一组织切片中注射³H-多巴胺（³H-DA）或摄取5-羟多巴胺（5-OHDA）后，将促肾上腺皮质激素（ACTH）免疫细胞化学与放射自显影相结合，研究了大鼠下丘脑弓状核（AN）中儿茶酚胺能终末与含ACTH神经元之间的突触关系。在AN中，ACTH样（ACTH-LI）免疫反应性神经细胞体和纤维接受了用³H-DA或5-OHDA标记的轴突终末的突触输入。这表明，儿茶酚胺能神经元，至少是含多巴胺（DA）和5-OHDA的神经元，可能通过大鼠下丘脑AN中的突触，在调节ACTH分泌或ACTH神经元的其他功能中发挥重要作用。
