Zoller L C, Quealy Buono J, Carr K, Ninke E, Vegso K
Acta Anat (Basel). 1987;128(3):256-63. doi: 10.1159/000146348.
The ultrastructural composition of 4 regions of rat preovulatory follicles was examined using stereological techniques following an intraperitoneal injection of tetrahydrocannabinol (THC), once each day, for 3 days prior to sacrifice on proestrus. Control rats were injected with solvent alone. Changes in nuclear, mitochondrial, lipid droplet and dense-body volume density were measured. No differences in volume density were noted in the theca or antral region of the membrana granulosa. Compared to controls, the mitochondrial volume density decreased in the peripheral region and the corona radiata. The volume density of lipid droplets decreased in the peripheral region. These changes, and their relationship to the roles of these regions in follicular steroidogenesis, are discussed.
在动情前期处死大鼠前3天，每天腹腔注射一次四氢大麻酚（THC），然后采用体视学技术检查大鼠排卵前卵泡4个区域的超微结构组成。对照大鼠仅注射溶剂。测量了细胞核、线粒体、脂滴和致密小体的体积密度。在卵泡膜或颗粒膜的窦状区域，体积密度没有差异。与对照组相比，外周区域和放射冠中的线粒体体积密度降低。外周区域中脂滴的体积密度降低。讨论了这些变化及其与这些区域在卵泡类固醇生成中作用的关系。
