Zoller L C, Buono J Q
Histochem J. 1987 Apr;19(4):195-202. doi: 10.1007/BF01680629.
The effects of delta 9-tetrahydrocannabinol on the activities of lactate and succinate dehydrogenases in the theca interna and membrana granulosa of rat preovulatory follicles have been analysed microdensitometrically using the same injection regime employed in a previous study on steroidogenic enzymes. A small but statistically significant (18%) decrease in succinate dehydrogenase activity was observed in the theca interna, but none in any region of the membrana granulosa. Lactate dehydrogenase activity was unaffected by THC administration. Thus, a dosage and regimen sufficient to cause significant decreases in the activities of steroidogenic enzymes had little effect on succinate and lactate dehydrogenases in rat preovulatory follicles.
使用先前一项关于类固醇生成酶的研究中采用的相同注射方案，通过显微密度测定法分析了δ9-四氢大麻酚对大鼠排卵前卵泡内膜和颗粒膜中乳酸脱氢酶和琥珀酸脱氢酶活性的影响。在内膜中观察到琥珀酸脱氢酶活性有小幅但具有统计学意义（18%）的下降，但在颗粒膜的任何区域均未观察到。乳酸脱氢酶活性不受四氢大麻酚给药的影响。因此，足以导致类固醇生成酶活性显著下降的剂量和方案对大鼠排卵前卵泡中的琥珀酸脱氢酶和乳酸脱氢酶几乎没有影响。
