龙血竭中同源异黄酮类衍生物。
Homoisoflavonoid derivatives from the red resin of Dracaena cochinchinensis.
机构信息
Modern Research Center for Traditional Chinese Medicine, School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 100029, China.
Modern Research Center for Traditional Chinese Medicine, School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 100029, China; Chinese Academy of Agricultural Sciences, Institute of Food Science and Technology, Beijing 100193, China.
出版信息
Fitoterapia. 2018 Nov;131:105-111. doi: 10.1016/j.fitote.2018.10.017. Epub 2018 Oct 16.
Five new homoisoflavonoid derivatives, including three meta-homoisoflavanes (1-3), one homoisoflavanone (4), and one homoisoflavan (5), along with five known analogues (6-10), were isolated from the red resin of Dracaena cochinchinensis (Chinese dragon's blood). Their structures were elucidated by analysis of spectroscopic data (1D and 2D NMR, IR, and HRESIMS). The absolute configuration of compound 1 was determined by single-crystal X-ray crystallographic analysis, and those of 2-5 were established on the basis of experimental and computed ECD data. Compounds 4, 6, and 9 exhibited moderate inhibition of nitric oxide production in lipopolysaccharide-stimulated BV-2 microglial cells with IC values of 60.4-75.6 μM.
从龙血树（Chinese dragon's blood）的红色树脂中分离得到了五个新的同型异黄酮衍生物，包括三个间型同型异黄烷（1-3）、一个同型异黄酮酮（4）和一个同型异黄烷（5），以及五个已知的类似物（6-10）。通过光谱数据分析（1D 和 2D NMR、IR 和 HRESIMS）阐明了它们的结构。通过单晶 X 射线晶体学分析确定了化合物 1 的绝对构型，通过实验和计算 ECD 数据确定了化合物 2-5 的绝对构型。化合物 4、6 和 9 对脂多糖刺激的 BV-2 小胶质细胞中一氧化氮生成具有中等抑制作用，IC 值为 60.4-75.6 μM。
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