Key Laboratory of Interface Science and Engineering in Advanced Materials, Taiyuan University of Technology, Ministry of Education, Taiyuan 030024, PR China; College of Materials Science and Engineering, Taiyuan University of Technology, Taiyuan 030024, PR China.
Agriculture and Forestry Technologically College, Hebei North University, Zhangjiakou 075000, PR China.
Int J Biol Macromol. 2019 Jan;121:1118-1125. doi: 10.1016/j.ijbiomac.2018.10.121. Epub 2018 Oct 16.
In this study, we fabricated a series of novel sodium alginate/ZnO hydrogel beads to optimize the release profile of curcumin (Cur) and to avoid the burst release associated with pure hydrogels, which were used to mitigate the weaknesses of Cur, such as rapid physiological clearance and sensitivity to ultraviolet (UV) light and alkaline solutions. The results show that the composite hydrogel beads exhibit good pH sensitivity and controlled-release capacity, which could prolong the residence time of Cur in the gastrointestinal tract. After exposure to UV irradiation for 6 h, the 1,1-Diphenyl-2-picrylhydrazyl (DPPH) scavenging capacity of Cur-loaded hydrogel beads was decreased by only 13.70%, whereas that of pure Cur decreased by 62.04% under the same conditions; therefore, the encapsulated Cur showed a higher antioxidant activity. The composite hydrogel beads protected the Cur from light degradation and can therefore prolong the antioxidant activity of Cur. These results are beneficial for the design of delivery systems to entrap and control the release of unstable drugs.
在这项研究中，我们制备了一系列新型的海藻酸钠/氧化锌水凝胶珠，以优化姜黄素（Cur）的释放曲线，并避免与纯水凝胶相关的突释，这是为了减轻 Cur 的一些弱点，如快速的生理清除率以及对紫外线（UV）光和碱性溶液的敏感性。结果表明，复合水凝胶珠具有良好的 pH 敏感性和控制释放能力，可以延长 Cur 在胃肠道中的停留时间。经 6 h 的紫外线照射后，载有 Cur 的水凝胶珠的 1,1-二苯基-2-苦基肼基（DPPH）清除能力仅下降了 13.70%，而相同条件下纯 Cur 下降了 62.04%；因此，包封的 Cur 表现出更高的抗氧化活性。复合水凝胶珠保护了 Cur 免受光降解，因此可以延长 Cur 的抗氧化活性。这些结果有利于设计用于包埋和控制不稳定药物释放的递送系统。
