有氧运动和抗阻运动可改善超重和肥胖乳腺癌幸存者的身体适应性、骨骼健康和生活质量：一项随机对照试验。
Aerobic and resistance exercise improves physical fitness, bone health, and quality of life in overweight and obese breast cancer survivors: a randomized controlled trial.
机构信息
Division of Biokinesiology and Physical Therapy, University of Southern California (USC), |1540 E. Alcazar St., CHP 155, Los Angeles, CA, 90089, USA.
Department of Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, 90033, USA.
出版信息
Breast Cancer Res. 2018 Oct 19;20(1):124. doi: 10.1186/s13058-018-1051-6.
BACKGROUND
Exercise is an effective strategy to improve quality of life and physical fitness in breast cancer survivors; however, few studies have focused on the early survivorship period, minorities, physically inactive and obese women, or tested a combined exercise program and measured bone health. Here, we report the effects of a 16-week aerobic and resistance exercise intervention on patient-reported outcomes, physical fitness, and bone health in ethnically diverse, physically inactive, overweight or obese breast cancer survivors.
METHODS
One hundred breast cancer survivors within 6 months of completing adjuvant treatment were assessed at baseline, post-intervention, and 3-month follow-up (exercise group only) for physical fitness, bone mineral density, serum concentrations of bone biomarkers, and quality of life. The exercise intervention consisted of moderate-vigorous (65-85% heart rate maximum) aerobic and resistance exercise thrice weekly for 16 weeks. Differences in mean changes for outcomes were evaluated using mixed-model repeated measure analysis.
RESULTS
At post-intervention, the exercise group was superior to usual care for quality of life (between group difference: 14.7, 95% CI: 18.2, 9.7; p < 0.001), fatigue (p < 0.001), depression (p < 0.001), estimated VO (p < 0.001), muscular strength (p < 0.001), osteocalcin (p = 0.01), and BSAP (p = 0.001). At 3-month follow-up, all patient-reported outcomes and physical fitness variables remained significantly improved compared to baseline in the exercise group (p < 0.01).
CONCLUSIONS
A 16-week combined aerobic and resistance exercise program designed to address metabolic syndrome in ethnically-diverse overweight or obese breast cancer survivors also significantly improved quality of life and physical fitness. Our findings further support the inclusion of supervised clinical exercise programs into breast cancer treatment and care.
TRIAL REGISTRATION
This trial is registered on ClinicalTrials.gov: NCT01140282 as of June 9, 2010.
背景
运动是提高乳腺癌幸存者生活质量和身体健康的有效策略；然而，很少有研究关注早期生存者、少数群体、身体不活跃和肥胖的女性，或测试综合运动计划并测量骨健康。在这里，我们报告了 16 周有氧运动和抗阻运动干预对不同种族、身体不活跃、超重或肥胖的乳腺癌幸存者的患者报告结局、身体适应性和骨健康的影响。
方法
100 名乳腺癌幸存者在辅助治疗完成后 6 个月内进行了基线、干预后和 3 个月随访（仅运动组）的身体适应性、骨矿物质密度、血清骨生物标志物浓度和生活质量评估。运动干预包括每周三次、中等至剧烈强度（心率最大的 65-85%）的有氧运动和抗阻运动，持续 16 周。使用混合模型重复测量分析评估结局的平均变化差异。
结果
干预后，运动组在生活质量（组间差异：14.7，95%置信区间：18.2，9.7；p<0.001）、疲劳（p<0.001）、抑郁（p<0.001）、估计 VO（p<0.001）、肌肉力量（p<0.001）、骨钙素（p=0.01）和 BSAP（p=0.001）方面均优于常规护理。在 3 个月随访时，运动组的所有患者报告结局和身体适应性变量与基线相比仍显著改善（p<0.01）。
结论
针对不同种族、超重或肥胖的乳腺癌幸存者代谢综合征设计的 16 周综合有氧运动和抗阻运动方案还显著改善了生活质量和身体适应性。我们的研究结果进一步支持将有监督的临床运动计划纳入乳腺癌治疗和护理中。
试验注册
该试验于 2010 年 6 月 9 日在 ClinicalTrials.gov 注册：NCT01140282。
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