Department of Education, Faculty of Education Sciences, University of Almería, Almería, Spain.
SPORT Research Group (CTS-1024), CERNEP Research Center, University of Almería, Almería, Spain.
J Cancer Surviv. 2023 Oct;17(5):1371-1385. doi: 10.1007/s11764-022-01192-1. Epub 2022 Mar 22.
This study assessed the effects of 12-week supervised resistance training combined with home-based physical activity on physical fitness, cancer-related fatigue, depressive symptoms, health-related quality of life (HRQoL), and life satisfaction in female breast cancer survivors.
A parallel-group, outcome assessor-blinded, randomized controlled trial included 60 female breast cancer survivors who had completed their core treatments within the previous 10 years. Through computer-generated simple randomization, participants were assigned to resistance training (RTG; two sessions/week for 12 weeks plus instructions to undertake ≥ 10,000 steps/d) or control (CG; ≥ 10,000 steps/d only). Outcomes were evaluated at baseline and week 12. Muscular strength was assessed with electromechanical dynamometry. A standardized full-body muscular strength score was the primary outcome. Secondary outcomes included cardiorespiratory fitness, shoulder mobility, cancer-related fatigue, depressive symptoms, HRQoL, and life satisfaction.
Thirty-two participants were assigned to RTG (29 achieved ≥ 75% attendance) and 28 to CG (all completed the trial). Intention-to-treat analyses revealed that the standardized full-body muscular strength score increased significantly in the RTG compared to the CG (0.718; 95% CI 0.361-1.074, P < 0.001, Cohen's d = 1.04). This increase was consistent for the standardized scores of upper-body (0.727; 95% CI 0.294-1.160, P = 0.001, d = 0.87) and lower-body (0.709; 95% CI 0.324-1.094, P = 0.001, d = 0.96) strength. There was no effect on cardiorespiratory fitness, shoulder flexion, cancer-related fatigue, depressive symptoms, HRQoL, or life satisfaction. The sensitivity analyses confirmed these results.
and implication for cancer survivors. In female breast cancer survivors who had completed their core treatments within the past 10 years, adding two weekly sessions of supervised resistance training to a prescription of home-based physical activity for 12 weeks produced a large increase in upper-, lower-, and full-body muscular strength, while other fitness components and patient-reported outcomes did not improve.
ISRCTN14601208.
本研究评估了 12 周监督阻力训练结合家庭体育活动对女性乳腺癌幸存者身体适应性、癌因性疲劳、抑郁症状、健康相关生活质量（HRQoL）和生活满意度的影响。
一项平行组、结局评估者设盲、随机对照试验纳入了 60 名在过去 10 年内完成核心治疗的女性乳腺癌幸存者。通过计算机生成的简单随机化，参与者被分配到阻力训练组（RTG；每周 2 次，共 12 周，并接受指令进行≥10000 步/天）或对照组（CG；仅进行≥10000 步/天）。在基线和第 12 周评估结局。肌肉力量采用机电动力计评估。标准化全身肌肉力量评分是主要结局。次要结局包括心肺适应性、肩部活动度、癌因性疲劳、抑郁症状、HRQoL 和生活满意度。
32 名参与者被分配到 RTG（29 名达到≥75%的出勤率），28 名被分配到 CG（所有参与者均完成了试验）。意向治疗分析显示，与 CG 相比，RTG 中的标准化全身肌肉力量评分显著增加（0.718；95%CI 0.361-1.074，P<0.001，Cohen's d = 1.04）。这一增加在上肢（0.727；95%CI 0.294-1.160，P=0.001，d = 0.87）和下肢（0.709；95%CI 0.324-1.094，P=0.001，d = 0.96）的标准化力量评分中均一致。心肺适应性、肩部活动度、癌因性疲劳、抑郁症状、HRQoL 或生活满意度均无变化。敏感性分析证实了这些结果。
本研究结果表明，对于过去 10 年内完成核心治疗的女性乳腺癌幸存者，在家庭体育活动处方中增加每周 2 次监督阻力训练 12 周，可显著提高上肢、下肢和全身肌肉力量，而其他健康相关体能成分和患者报告结局无改善。
ISRCTN83321336。
