Cao Ming, Li Yuan, Gu ZhuQin, Mi TaoMian, Xu XiTong, Ma CuiHong, Chen MeiJie, Wu MengMeng, Chan Piu
Department of Neurobiology and Neurology, Xuanwu Hospital of Capital Medical University, Beijing 100053, China.
Parkinson Disease Center of Beijing Institute of Brain Disorders, Beijing 100053, China; Beijing Key Laboratory on Parkinson's Disease, Beijing 100053, China.
J Clin Neurosci. 2019 Feb;60:68-72. doi: 10.1016/j.jocn.2018.10.023. Epub 2018 Oct 16.
Hyposmia is a common non-motor symptom occurring in Parkinson's disease (PD), and has been included in the diagnostic criteria. Although a version of the Brief Smell Identification Test (B-SIT) has been developed specifically for Chinese populations, there have been no reports of the utility of this test in the diagnosis of PD in China.
Considering the influence of cultural factors on olfactory test findings, we sought to investigate the utility and efficiency of the B-SIT in Chinese PD patients.
PD patients were recruited from the Movement Disorder Clinic of Xuanwu Hospital, and healthy controls were recruited from the Beijing Longitudinal Study on Aging Cohort II, between 2015 and 2016. The B-SIT was used for olfactory function testing in all subjects, and the familiarity of 59 odors questionnaire was performed for the investigation of familiarity of odors.
A sample of 275 subjects participated in the study, including 112 healthy controls and 163 PD patients. The sensitivity (64.1%), specificity (83.9%), positive predictive value (83.5%) and negative predictive value (64.8%) for identifying PD were measured with the B-SIT. The consistency values between the results of self-reported smell loss and hyposmia identified by B-SIT in control and PD groups were 74.8% and 64.2%, respectively. Most of the odors in the B-SIT were familiar to people in the Chinese population, based on a survey of 3356 subjects using a familiarity questionnaire.
It is recommended to use the B-SIT olfactory test instead of self-reported smell loss for PD diagnosis for Chinese.
嗅觉减退是帕金森病（PD）常见的非运动症状，已被纳入诊断标准。尽管已经专门为中国人群开发了一个版本的简易嗅觉识别测试（B-SIT），但在中国尚无关于该测试在PD诊断中效用的报道。
考虑到文化因素对嗅觉测试结果的影响，我们试图研究B-SIT在中国PD患者中的效用和效率。
2015年至2016年期间，从宣武医院运动障碍门诊招募PD患者，并从北京老年纵向研究队列II中招募健康对照。所有受试者均使用B-SIT进行嗅觉功能测试，并通过59种气味熟悉度问卷来调查对气味的熟悉程度。
275名受试者参与了该研究，包括112名健康对照和163名PD患者。使用B-SIT测量识别PD的敏感性（64.1%）、特异性（83.9%）、阳性预测值（83.5%）和阴性预测值（64.8%）。在对照组和PD组中，自我报告的嗅觉丧失结果与B-SIT识别的嗅觉减退结果之间的一致性值分别为74.8%和64.2%。根据对3356名受试者使用熟悉度问卷的调查，B-SIT中的大多数气味在中国人群中是熟悉的。
建议使用B-SIT嗅觉测试而非自我报告的嗅觉丧失来对中国人进行PD诊断。
