Basu Ayan, Ray Yogiraj, Bhowmik Pratik, Rahman Mehebubar, Goswami Rama Prosad
Former RMO cum Clinical Tutor, Tropical Medicine; Currently working as Post Doctoral Trainee,Infectious Diseases, Department of Internal Medicine, All India Institute of Medical Sciences, New Delhi.
Assistant Professor.
J Assoc Physicians India. 2018 Jan;66(1):98-9.
A 22 year old male Indian patient presented with high grade fever, multiple joint pain, low back pain, generalized body ache since 6 months and erythematous pruritic rashes and atypical annular target like lesions over face, arm, leg and back and ulcers on hard palate and buccal mucosa for 2 months. Laboratory investigations showed a speckled pattern anti-nuclear antibody with a titer >1:160 and positive SS-A, dsDNA auto-antibodies and Rheumatoid factor. Diagnosis of Rowell's syndrome was made based on clinical and laboratory finding and the patient was treated with oral prednisolone (50 mg/day), hydroxychloroquine (200 mg q12h) and pulse cyclophosphamide (700 mg) chemotherapy. Majority of skin lesions and oral ulcerations subsided after 4 weeks of therapy. Till date only 11 male patients out of the total 71 cases of Rowell's syndrome were reported in the world's literature.
一名22岁的印度男性患者，6个月来一直出现高热、多关节疼痛、腰痛、全身疼痛，2个月来面部、手臂、腿部和背部出现红斑瘙痒性皮疹及非典型环形靶样皮损，硬腭和颊黏膜出现溃疡。实验室检查显示抗核抗体呈斑点型，滴度>1:160，SS-A、双链DNA自身抗体及类风湿因子阳性。根据临床和实验室检查结果诊断为罗威尔综合征，患者接受口服泼尼松龙（50毫克/天）、羟氯喹（200毫克，每12小时1次）及脉冲环磷酰胺（700毫克）化疗。治疗4周后，大多数皮肤损害和口腔溃疡消退。迄今为止，世界文献中报道的罗威尔综合征71例病例中，仅有11例男性患者。
