School of Food Science and Technology, National Engineering Research Center of Seafood, Dalian Polytechnic University, Dalian 116034, PR China.
School of Food Science and Technology, National Engineering Research Center of Seafood, Dalian Polytechnic University, Dalian 116034, PR China; National & Local Joint Engineering Laboratory for Marine Bioactive Polysaccharide Development and Application, Dalian Polytechnic University, Dalian 116034, PR China.
Int J Biol Macromol. 2019 Jan;121:996-1004. doi: 10.1016/j.ijbiomac.2018.10.087. Epub 2018 Oct 17.
Polysaccharides from Laminaria japonica (LJPs) are reported to have various functional properties, but the effects and mechanisms of LJPs on obesity and its related diseases are unclear. This study demonstrated that LJPs prevented diet-induced obesity in a mice model, and improved obesity-related parameters, e.g. fat accumulation in the liver and adipose tissues, body composition, lipids profile, and the morphology of the intestine. Such effects were associated with the modulation of the gut microbiota, involving some members of the Bacteroidetes phylum. Changes in the gut microbiota could improve nutrient utilization, increase microbial metabolites production, and thus regulate lipids metabolism in the body. In short, it sought to indicate that L. japonica can be developed as food supplement for the improvement of metabolic syndrome and the human gut health.
裙带菜多糖（LJPs）具有多种功能特性，但其对肥胖及其相关疾病的作用和机制尚不清楚。本研究表明，LJPs 可预防小鼠模型的饮食诱导肥胖，并改善肥胖相关参数，如肝脏和脂肪组织中的脂肪堆积、身体成分、脂质谱和肠道形态。这些作用与肠道微生物群的调节有关，涉及厚壁菌门的一些成员。肠道微生物群的变化可以改善营养物质的利用，增加微生物代谢产物的产生，从而调节体内的脂质代谢。简而言之，它试图表明裙带菜可以作为改善代谢综合征和人类肠道健康的食品补充剂进行开发。
