Ma Jianxia, Sun Jianqin, Bai Huijing, Ma Houlian, Wang Ke, Wang Jun, Yu Xiaofeng, Pan Yiru, Yao Jianfeng
Department of Gastroenterology, Huadong Hospital Affiliated to Fudan University, Shanghai, People's Republic of China.
Clinical Nutrition Center, Huadong Hospital Affiliated to Fudan University, Shanghai, People's Republic of China.
J Multidiscip Healthc. 2022 Oct 20;15:2407-2418. doi: 10.2147/JMDH.S379708. eCollection 2022.
This study was to explore the influence of flax seeds on the gut microbiota of elderly patients with functional constipation.
Sixty elderly patients (68.68±8.73 years) with functional constipation were recruited between January 2018 and March 2018. They received oral flax seeds (50 g/d) for one month. Bowel habits and adverse events were recorded before and after treatment. Fresh stool was collected before and after treatment and the amplification product of 16S rRNA V5 region was sequenced using the next-generation sequencing technique on the Ion Torrent PGM platform. The gut microbiota were analyzed before and after flax seeds treatment in the same subject.
Flax-seed treatment significantly increased the frequency of defecation and decreased abdominal distension in elderly patients with chronic constipation. The majority of gut bacteria belonged to the phyla of Firmicutes, Bacteroidetes, and Proteobacteria, accounting for 98.71%. After flax seeds treatment, the diversity of bacterial clusters significantly increased with increases of . The abundance of in patients with chronic constipation was significantly lower than healthy controls, while after flax seed treatment. might be the predominant genus accounting for the therapeutic effect of flax seeds.
Flax seeds may improve the defecation in elderly patients with chronic constipation and change intestinal microecological structure. Thus, flax seeds may serve as an effective diet supplement in the management of chronic constipation.
本研究旨在探讨亚麻籽对老年功能性便秘患者肠道微生物群的影响。
2018年1月至2018年3月招募了60例老年功能性便秘患者（68.68±8.73岁）。他们接受口服亚麻籽（50克/天），为期一个月。记录治疗前后的排便习惯和不良事件。治疗前后收集新鲜粪便，并在Ion Torrent PGM平台上使用下一代测序技术对16S rRNA V5区域的扩增产物进行测序。对同一受试者在亚麻籽治疗前后的肠道微生物群进行分析。
亚麻籽治疗显著增加了老年慢性便秘患者的排便频率，减轻了腹胀。大多数肠道细菌属于厚壁菌门、拟杆菌门和变形菌门，占98.71%。亚麻籽治疗后，细菌簇的多样性显著增加，随着……的增加而增加。慢性便秘患者中……的丰度显著低于健康对照，而亚麻籽治疗后……。……可能是占亚麻籽治疗效果的主要属。
亚麻籽可能改善老年慢性便秘患者的排便情况，并改变肠道微生态结构。因此，亚麻籽可作为慢性便秘管理中的一种有效饮食补充剂。
