Division of Viral Hepatitis, National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia.
Division of Viral Hepatitis, National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia.
Am J Prev Med. 2018 Nov;55(5):633-641. doi: 10.1016/j.amepre.2018.05.029.
Perinatal transmission is an increasingly important mode of hepatitis C virus transmission. The authors characterized U.S. births among hepatitis C virus-infected women and evaluated trends in hepatitis C virus testing and positivity in women of childbearing age, pregnant women, and children aged less than 5years.
In 2017, National Center for Health Statistics birth certificate data (48 states and District of Columbia) were analyzed to assess the number of hepatitis C virus-infected women delivering live births in 2015, and commercial laboratory data were analyzed to assess hepatitis C virus testing and positivity among women of childbearing age, pregnant women, and children aged <5years from 2011 to 2016.
In 2015, a total of 0.38% (n=14,417) of live births were delivered by hepatitis C virus-infected women. Births delivered by hepatitis C virus-infected women, compared with births overall, occurred more often in women who were aged 20-29years (60.7% vs 50.9%); white, non-Hispanic (80.2% vs 52.8%); covered by Medicaid or other government insurance (79.2% vs 43.9%); and had rural residence (26.0% vs 14.0%). From 2011 to 2016 laboratory data, among women of childbearing age, hepatitis C virus testing increased by 39%, from 6.1% to 8.4%, and positivity increased by 36%, from 4.4% to 6.0%. Among pregnant women, hepatitis C virus testing increased by 135%, from 5.7% to 13.4%, and positivity increased by 39%, from 2.6% to 3.6%. Among children, hepatitis C virus testing increased by 25%, from 0.47% to 0.59%, and positivity increased by 13%, from 3.6% to 4.0%.
The potential for perinatal hepatitis C virus transmission exists. Expanded hepatitis C virus testing guidelines may address the burden of disease in this population.
围产期传播是丙型肝炎病毒传播的一种越来越重要的模式。作者描述了美国丙型肝炎病毒感染女性的分娩情况，并评估了育龄妇女、孕妇和 5 岁以下儿童丙型肝炎病毒检测和阳性率的趋势。
2017 年，分析了国家卫生统计中心出生证明数据（48 个州和哥伦比亚特区），以评估 2015 年丙型肝炎病毒感染妇女活产数量，分析商业实验室数据，以评估 2011 年至 2016 年育龄妇女、孕妇和 5 岁以下儿童丙型肝炎病毒检测和阳性率。
2015 年，共有 0.38%（n=14417）的活产由丙型肝炎病毒感染妇女分娩。与总体分娩相比，丙型肝炎病毒感染妇女分娩更常见于年龄在 20-29 岁的妇女（60.7%比 50.9%）；白人，非西班牙裔（80.2%比 52.8%）；由医疗补助或其他政府保险覆盖（79.2%比 43.9%）；以及农村居民（26.0%比 14.0%）。2011 年至 2016 年实验室数据显示，在育龄妇女中，丙型肝炎病毒检测率从 6.1%增加到 8.4%，增加了 39%；阳性率从 4.4%增加到 6.0%，增加了 36%。在孕妇中，丙型肝炎病毒检测率从 5.7%增加到 13.4%，增加了 135%；阳性率从 2.6%增加到 3.6%，增加了 39%。在儿童中，丙型肝炎病毒检测率从 0.47%增加到 0.59%，增加了 25%；阳性率从 3.6%增加到 4.0%，增加了 13%。
存在围产期丙型肝炎病毒传播的可能性。扩大丙型肝炎病毒检测指南可能会解决这一人群的疾病负担。
Zotero 插件