Department of Geriatrics, The Second Affiliated Hospital, Key Laboratory for Aging & Disease, Nanjing Medical University, Nanjing, Jiangsu 210011, PR China.
Department of Geriatrics, The Second Affiliated Hospital, Key Laboratory for Aging & Disease, Nanjing Medical University, Nanjing, Jiangsu 210011, PR China.
Biochem Biophys Res Commun. 2018 Nov 17;506(1):204-210. doi: 10.1016/j.bbrc.2018.09.159. Epub 2018 Oct 17.
The role of retinol-binding protein 4 (RBP4) in patients with coronary artery disease (CAD) with different sexes has not been clearly established. Sex hormones, especially testosterone (T) and estradiol (E2), have been considered to play an important role in CAD. This study aimed to investigate the role of RBP4 and the possible association between RBP4 and T and E2 in CAD. The study included 658 individuals who underwent coronary angiography (CAG); they were assigned to CAD group (n = 440) and controls (n = 218). CAD group was subdivided into three subgroups. Serum RBP4 and T were assayed by enzyme-linked immunosorbent assay. Serum E2 was measured using electrochemiluminescence immunoassay. For men, RBP4 levels were lower in CAD group, especially those with acute myocardial infarction, than in controls (P < 0.05, P < 0.01, respectively). For women, no significant difference was found in RBP4 levels between both groups. RBP4 was positively correlated with T in male patients with CAD (r = 0.124, P < 0.05). Logistic regression analysis showed that RBP4 was a protective factor for CAD (odds ratio 0.975, 95% confidence interval 0.958-0.993; P = 0.007). In conclusion, RBP4 levels were significantly decreased and positively related with T in men with CAD. Higher RBP4 levels were associated with lower risk of CAD. RBP4 may play a potential protective role for CAD among men.
视黄醇结合蛋白 4（RBP4）在不同性别冠心病（CAD）患者中的作用尚未明确。性激素，尤其是睾酮（T）和雌二醇（E2），被认为在 CAD 中发挥重要作用。本研究旨在探讨 RBP4 的作用，以及 RBP4 与 T 和 E2 之间的可能关联在 CAD 中的作用。研究纳入了 658 例行冠状动脉造影（CAG）的个体；他们被分为 CAD 组（n=440）和对照组（n=218）。CAD 组进一步分为三个亚组。酶联免疫吸附试验检测血清 RBP4 和 T，电化学发光免疫分析法检测血清 E2。对于男性，CAD 组（尤其是急性心肌梗死患者）的 RBP4 水平低于对照组（P<0.05，P<0.01）。对于女性，两组之间的 RBP4 水平没有显著差异。CAD 男性患者的 RBP4 与 T 呈正相关（r=0.124，P<0.05）。Logistic 回归分析显示，RBP4 是 CAD 的保护因素（比值比 0.975，95%置信区间 0.958-0.993；P=0.007）。结论：CAD 男性的 RBP4 水平显著降低，且与 T 呈正相关。较高的 RBP4 水平与 CAD 风险降低相关。RBP4 可能在男性 CAD 中发挥潜在的保护作用。
