Action and Cognition Laboratory, School of Psychology and Exercise Science, Murdoch University, Perth, Australia.
Centre for Clinical Research, Faculty of Medicine, University of Queensland, Brisbane, Australia.
Neuroimage. 2019 Jan 15;185:490-512. doi: 10.1016/j.neuroimage.2018.10.044. Epub 2018 Oct 19.
Response inhibition, the ability to withhold a dominant and prepotent response following a change in circumstance or sensory stimuli, declines with advancing age. While non-invasive brain stimulation (NiBS) has shown promise in alleviating some cognitive and motor functions in healthy older individuals, NiBS research focusing on response inhibition has mostly been conducted on younger adults. These extant studies have primarily focused on modulating the activity of distinct neural regions known to be critical for response inhibition, including the right inferior frontal gyrus (rIFG) and the pre-supplementary motor area (pre-SMA). However, given that changes in structural and functional connectivity have been associated with healthy aging, this review proposes that NiBS protocols aimed at modulating the functional connectivity between the rIFG and pre-SMA may be the most efficacious approach to investigate-and perhaps even alleviate-age-related deficits in inhibitory control.
反应抑制是指在环境或感觉刺激发生变化后，抑制主导和优势反应的能力，随着年龄的增长而下降。虽然非侵入性脑刺激 (NiBS) 已显示出在改善健康老年人的一些认知和运动功能方面的潜力，但针对反应抑制的 NiBS 研究主要集中在年轻成年人身上。这些现有的研究主要集中在调节已知对反应抑制至关重要的不同神经区域的活动，包括右额下回 (rIFG) 和补充运动前区 (pre-SMA)。然而，鉴于结构和功能连接的变化与健康衰老有关，因此本综述提出，旨在调节 rIFG 和 pre-SMA 之间功能连接的 NiBS 方案可能是研究甚至可能缓解抑制控制相关年龄缺陷的最有效方法。
