Kang Dong Woo, Lim Hyun Kook, Joo Soo-Hyun, Lee Na Rae, Lee Chang-Uk
Department of Psychiatry, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
Department of Psychiatry, Yeouido St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
Dement Geriatr Cogn Disord. 2018;46(3-4):229-242. doi: 10.1159/000493167. Epub 2018 Oct 19.
Previous research has separated spatial patterns of intra- and interregional intrinsic brain connectivity, as evaluated by regional homogeneity (ReHo) and functional connectivity (FC), respectively, in prodromal Alzheimer's disease (AD). Moreover, the intra- and interregional intrinsic brain connectivities have been demonstrated to have a significant relationship with each other.
To explore FCs from brain regions which display a difference in ReHo between an amnestic mild cognitive impairment (aMCI) group and healthy controls (HC) and to examine the relationship of intra- and interregional intrinsic brain connectivity to cognitive function in both groups.
Thirty-four subjects with aMCI and 38 HC underwent 3T MRI scanning and a battery of neuropsychological tests.
The aMCI group exhibited significantly higher ReHo in the left putamen and lower ReHo in the left inferior temporal gyrus than the HC. Furthermore, both groups showed a distinctive functional connectivity pattern seeded from 2 regions of interest which exhibited significant ReHo differences between the groups. In the HC group, only ReHo exhibited significant associations with memory performance, but in the aMCI group, only FC seeded from the left inferior temporal gyrus showed significant correlations with memory performance.
By approaching both intra- and interregional intrinsic brain activities in the early stages of AD, the findings of this research provide insights into the early pathogenesis of AD as related to memory performance.
先前的研究分别通过区域同质性（ReHo）和功能连接性（FC）评估了前驱期阿尔茨海默病（AD）中脑内和脑区间内在脑连接的空间模式。此外，脑内和脑区间内在脑连接性已被证明彼此之间存在显著关系。
探索遗忘型轻度认知障碍（aMCI）组与健康对照（HC）之间在ReHo上存在差异的脑区的功能连接，并检查两组脑内和脑区间内在脑连接与认知功能的关系。
34名aMCI受试者和38名HC接受了3T磁共振成像扫描和一系列神经心理学测试。
与HC相比，aMCI组左侧壳核的ReHo显著更高，而左侧颞下回的ReHo更低。此外，两组均显示出由两个感兴趣区域引出的独特功能连接模式，这两个区域在两组之间表现出显著的ReHo差异。在HC组中，只有ReHo与记忆表现显著相关，但在aMCI组中，只有从左侧颞下回引出的FC与记忆表现显著相关。
通过研究AD早期脑内和脑区间的内在脑活动，本研究结果为AD与记忆表现相关的早期发病机制提供了见解。
