Institut Jacques Monod, CNRS UMR7592, Université Paris-Diderot, 75013 Paris, France.
Institut Systématique Évolution Biodiversité (ISYEB), Centre National de Recherche Scientifique, MNHN, Sorbonne Université, EPHE, 57 rue Cuvier, CP 50, 75005 Paris, France.
Curr Biol. 2018 Nov 5;28(21):3450-3457.e13. doi: 10.1016/j.cub.2018.08.047. Epub 2018 Oct 18.
Diverse traits often covary between species [1-3]. The possibility that a single mutation could contribute to the evolution of several characters between species [3] is rarely investigated as relatively few cases are dissected at the nucleotide level. Drosophila santomea has evolved additional sex comb sensory teeth on its legs and has lost two sensory bristles on its genitalia. We present evidence that a single nucleotide substitution in an enhancer of the scute gene contributes to both changes. The mutation alters a binding site for the Hox protein Abdominal-B in the developing genitalia, leading to bristle loss, and for another factor in the developing leg, leading to bristle gain. Our study suggests that morphological evolution between species can occur through a single nucleotide change affecting several sexually dimorphic traits. VIDEO ABSTRACT.
物种之间的多种特征通常是相关的[1-3]。很少有研究调查单个突变是否可能导致物种之间几个特征的进化[3]，因为在核苷酸水平上很少有案例被剖析。Drosophila santomea 在其腿部上进化出了额外的性梳感觉牙齿，而在生殖器上失去了两根感觉刚毛。我们提出的证据表明，scute 基因增强子中的一个单核苷酸取代导致了这两种变化。该突变改变了发育中的生殖器中 Abdominal-B Hox 蛋白的结合位点，导致刚毛丢失，并改变了发育中的腿部中的另一个因素，导致刚毛增加。我们的研究表明，物种之间的形态进化可以通过单个影响几个性二态特征的核苷酸变化来发生。视频摘要。
