Institute of Epidemiology, Faculty of Medicine, University of Belgrade, 11000 Belgrade, Serbia.
Institute of Medical Statistics and Informatics, Faculty of Medicine, University of Belgrade, 11000 Belgrade, Serbia.
Medicina (Kaunas). 2018 Mar 20;54(1):5. doi: 10.3390/medicina54010005.
: To assess incidence and mortality trends of acute myeloid leukemia (AML) in Belgrade (Serbia) in a 15-year period (from 1999 to 2013). Data were obtained from the Cancer Registry of Serbia, Institute of Public Health of Serbia. Standardized incidence and mortality rates per 100,000 inhabitants were calculated by direct standardization method using World Standard Population. Analysis of raw data indicated single-digit numbers per year and per 5-year age cohorts. Therefore, we merged years of diagnosis to three-year intervals, creating so-called "moving averages". We also merged study population to 10-year age cohorts. Both incidence and mortality rates increased with age, i.e., the lowest rates were observed in the youngest age groups and the highest rates were observed in oldest age groups. In all age groups, except the youngest (15⁻24 years), AML incidence was statistically significantly higher in men compared with women. Average age-adjusted incidence was 2.73/100,000 (95% confidence interval (CI) 2.28⁻3.71). Average age-adjusted mortality was 1.81/100,000 (95% CI 1.30⁻2.26). Overall, there were no significant changes in incidence trend. Age-adjusted incidence rates had increasing tendency among men aged 65⁻74 years (B = 0.80, standard error (SE) = 0.11; = 0.005) and in total population aged 65⁻74 years (B = 0.41, SE = 0.09; = 0.023). Increasing tendency in incidence of AML among women was observed in age group >75 years (B = 0.63, SE = 0.14; = 0.019). No changes of mortality trend were observed. There was no significant change in trends of AML from 1999 to 2013 in the population of Belgrade.
: 评估 15 年间（1999 年至 2013 年）在贝尔格莱德（塞尔维亚）急性髓系白血病（AML）的发病率和死亡率趋势。数据来自塞尔维亚癌症登记处和塞尔维亚公共卫生研究所。采用世界标准人口直接标准化法计算每 10 万人的标准化发病率和死亡率。原始数据分析表明，每年和每 5 岁年龄组的数字都为个位数。因此，我们将诊断年份合并为三年间隔，创建所谓的“移动平均值”。我们还将研究人群合并为 10 岁年龄组。发病率和死亡率均随年龄增长而增加，即最低发病率见于最年轻的年龄组，最高见于最年长的年龄组。除了最年轻的年龄组（15-24 岁）外，所有年龄组中男性 AML 的发病率均显著高于女性。平均年龄调整发病率为 2.73/100,000（95%置信区间（CI）2.28-3.71）。平均年龄调整死亡率为 1.81/100,000（95%CI 1.30-2.26）。总体而言，发病率趋势没有明显变化。年龄调整后的发病率在 65-74 岁的男性中呈上升趋势（B = 0.80，标准误差（SE）= 0.11； = 0.005）和 65-74 岁的总人口中呈上升趋势（B = 0.41，SE = 0.09； = 0.023）。在年龄组 >75 岁的女性中，AML 的发病率呈上升趋势（B = 0.63，SE = 0.14； = 0.019）。死亡率趋势没有变化。1999 年至 2013 年期间，贝尔格莱德人群中 AML 的发病趋势没有明显变化。
