Chai Yaqiong, Chen Jieshen, Galarza Cristina, Sluman Maayke A, Xu Botian, Vu Chau Q, Richard Edo, Mulder Barbara, Tamrazi Benita, Lepore Natasha, Mutsaerts Henri J M M, Wood John C
CIBORG laboratory, Department of Radiology, Children's Hospital Los Angeles, CA, USA.
Department of Biomedical Engineering, University of Southern California, CA, USA.
Proc IEEE Int Symp Biomed Imaging. 2018 Apr;2018:1309-1312. doi: 10.1109/ISBI.2018.8363812. Epub 2018 May 24.
Long-term outcomes for Tetralogy of Fallot (TOF) have improved dramatically in recent years, but survivors are still afflicted by cerebral damage. In this paper, we characterized the prevalence and predictors of cerebral silent infarction (SCI) and their relationship to cerebral blood flow (CBF) in 46 adult TOF patients. We calculated both whole brain and regional CBF using 2D arterial spin labeling (ASL) images, and investigated the spatial overlap between voxel-wise CBF values and white matter hyperintensities (WMHs) identified from T2-FLAIR images. SCIs were found in 83% of subjects and were predicted by the year of the patient's first cardiac surgery and patient's age at scanning (combined r 0.44). CBF was not different in brain regions prone to stroke compared with healthy white matter.
近年来，法洛四联症（TOF）的长期预后有了显著改善，但幸存者仍受脑损伤困扰。在本文中，我们对46例成年TOF患者脑静息性梗死（SCI）的患病率、预测因素及其与脑血流量（CBF）的关系进行了特征分析。我们使用二维动脉自旋标记（ASL）图像计算全脑和局部CBF，并研究体素水平的CBF值与T2-FLAIR图像中识别出的白质高信号（WMH）之间的空间重叠。83%的受试者存在SCI，其预测因素为患者首次心脏手术年份和扫描时的年龄（综合相关系数为0.44）。与健康白质相比，易发生卒中的脑区CBF无差异。
